6.2.1.2: medium-chain acyl-CoA ligase
This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.2
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6.2.1.2
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desaturase
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polyunsaturated
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pufas
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docosahexaenoic
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arachidonic
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monounsaturated
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eicosapentaenoic
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linoleic
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desaturation
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elovl5
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unsaturated
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lc-pufas
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acyl-coas
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oleic
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stearoyl-coa
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very-long-chain
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vlcfas
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palmitoleic
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delta6
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stearic
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alpha-linolenic
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linseed
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gamma-linolenic
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alpina
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stargardt
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mortierella
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isochrysis
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3-ketoacyl-coa
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erucic
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cis-vaccenic
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vaccenic
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dihomo-gamma-linolenic
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medicine
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stearidonic
- 6.2.1.2
-
desaturase
-
polyunsaturated
-
pufas
-
docosahexaenoic
-
arachidonic
-
monounsaturated
-
eicosapentaenoic
-
linoleic
-
desaturation
- elovl5
- unsaturated
-
lc-pufas
- acyl-coas
-
oleic
- stearoyl-coa
-
very-long-chain
-
vlcfas
-
palmitoleic
-
delta6
-
stearic
-
alpha-linolenic
-
linseed
-
gamma-linolenic
- alpina
- stargardt
- mortierella
- isochrysis
- 3-ketoacyl-coa
-
erucic
-
cis-vaccenic
-
vaccenic
-
dihomo-gamma-linolenic
- medicine
-
stearidonic
Reaction
Synonyms
Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase
ECTree
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Disease
Disease on EC 6.2.1.2 - medium-chain acyl-CoA ligase
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Adenocarcinoma
An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use.
Adrenoleukodystrophy
ABC Subfamily D Proteins and Very Long Chain Fatty Acid Metabolism as Novel Targets in Adrenoleukodystrophy.
Breast Neoplasms
Plasmalogen Deficiency and Overactive Fatty Acid Elongation Biomarkers in Serum of Breast Cancer Patients Pre- and Post-Surgery-New Insights on Diagnosis, Risk Assessment, and Disease Mechanisms.
Cardiovascular Diseases
Elovl6: a new player in fatty acid metabolism and insulin sensitivity.
Colitis, Ulcerative
Mucosal enzyme activity for butyrate oxidation; no defect in patients with ulcerative colitis.
Cystic Fibrosis
Increased elongase 6 and ?9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis.
Dehydration
Purification of the acyl-CoA elongase complex from developing rapeseed and characterization of the 3-ketoacyl-CoA synthase and the 3-hydroxyacyl-CoA dehydratase.
Dehydration
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
Dermatitis, Atopic
Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.
Diabetes Mellitus, Type 2
Plasma fatty acids as predictors of glycaemia and type 2 diabetes.
Hepatitis B
Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B.
Ichthyosis
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Infectious Mononucleosis
Interleukin-18, interferon-gamma, IP-10, and Mig expression in Epstein-Barr virus-induced infectious mononucleosis and posttransplant lymphoproliferative disease.
Insulin Resistance
Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children.
Insulin Resistance
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Insulin Resistance
Lower estimates of delta-5 desaturase and elongase activity are related to adverse profiles for several metabolic risk factors in young Japanese women.
Intellectual Disability
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Liver Cirrhosis
Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease.
long-chain-aldehyde dehydrogenase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Macular Degeneration
A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32-C36 acyl phosphatidylcholines.
Macular Degeneration
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3.
Macular Degeneration
Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy.
Malnutrition
Lipids, lipoproteins, and fatty acids during infantile marasmus in the Fès area of Morocco.
Metabolic Diseases
Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children.
Metabolic Syndrome
Plasma fatty acids profile and estimated elongase and desaturases activities in Tunisian patients with the metabolic syndrome.
Metabolic Syndrome
The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.
Neoplasms
An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use.
Obesity
Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling.
Obesity
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Protein Deficiency
Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Quadriplegia
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Retinal Degeneration
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3.
Sjogren-Larsson Syndrome
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Spinocerebellar Ataxias
Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38.
Stargardt Disease
Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy.
Starvation
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.
Tuberculosis
Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription.
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