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6.2.1.2: medium-chain acyl-CoA ligase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.2

Reaction

ATP
+
a medium-chain fatty acid
+
CoA
=
AMP
+
diphosphate
+
a medium-chain acyl-CoA

Synonyms

Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.2 medium-chain acyl-CoA ligase

Natural Substrates Products

Natural Substrates Products on EC 6.2.1.2 - medium-chain acyl-CoA ligase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a medium chain fatty acid or an aromatic acid or an arylacetic acid + CoA
?
show the reaction diagram
-
the enzyme catalyzes the first reaction of glycine conjugation, which is an important route of detoxification of many xenobiotic and endogenous carboxylic acids
-
-
?
ATP + L-(+)-3-hydroxybutyrate + CoA
?
show the reaction diagram
-
enzyme reesterifies CoA and L-(+)-3-hydroxybutyrate. It is required for the production of L-(+)-3-hydroxybutyrate in rat liver
-
-
?
ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
show the reaction diagram
enzymatic activation of phenylacetic acid to phenylacetyl-CoA is an important step in the biosynthesis of the beta-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum, CoA esters of PAA and phenoxyacetic acid act as acyl donor in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V
-
-
?
additional information
?
-