6.2.1.2: medium-chain acyl-CoA ligase
This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.2
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6.2.1.2
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desaturase
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polyunsaturated
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pufas
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docosahexaenoic
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arachidonic
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monounsaturated
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eicosapentaenoic
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linoleic
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desaturation
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elovl5
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unsaturated
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lc-pufas
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acyl-coas
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oleic
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stearoyl-coa
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very-long-chain
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vlcfas
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palmitoleic
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delta6
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stearic
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alpha-linolenic
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linseed
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gamma-linolenic
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alpina
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stargardt
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mortierella
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isochrysis
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3-ketoacyl-coa
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erucic
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cis-vaccenic
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vaccenic
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dihomo-gamma-linolenic
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medicine
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stearidonic
- 6.2.1.2
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desaturase
-
polyunsaturated
-
pufas
-
docosahexaenoic
-
arachidonic
-
monounsaturated
-
eicosapentaenoic
-
linoleic
-
desaturation
- elovl5
- unsaturated
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lc-pufas
- acyl-coas
-
oleic
- stearoyl-coa
-
very-long-chain
-
vlcfas
-
palmitoleic
-
delta6
-
stearic
-
alpha-linolenic
-
linseed
-
gamma-linolenic
- alpina
- stargardt
- mortierella
- isochrysis
- 3-ketoacyl-coa
-
erucic
-
cis-vaccenic
-
vaccenic
-
dihomo-gamma-linolenic
- medicine
-
stearidonic
Reaction
Synonyms
Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase
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Natural Substrates Products
Natural Substrates Products on EC 6.2.1.2 - medium-chain acyl-CoA ligase
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REACTION DIAGRAM
ATP + a medium chain fatty acid or an aromatic acid or an arylacetic acid + CoA
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the enzyme catalyzes the first reaction of glycine conjugation, which is an important route of detoxification of many xenobiotic and endogenous carboxylic acids
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ATP + L-(+)-3-hydroxybutyrate + CoA
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enzyme reesterifies CoA and L-(+)-3-hydroxybutyrate. It is required for the production of L-(+)-3-hydroxybutyrate in rat liver
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ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
enzymatic activation of phenylacetic acid to phenylacetyl-CoA is an important step in the biosynthesis of the beta-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum, CoA esters of PAA and phenoxyacetic acid act as acyl donor in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V
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major enzyme for glycine conjugation of benzoic acids with electron-donating groups in bovine liver mitochondria
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additional information
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the enzyme catalyzes the first reaction of glycine conjugation
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additional information
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the enzyme is responsible for glycine conjugation
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additional information
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the enzyme is involved in the metabolism of fatty acid during mycobacterial survival in macrophages
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