6.2.1.2: medium-chain acyl-CoA ligase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.

Reaction

Synonyms

Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.2 medium-chain acyl-CoA ligase

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Results	in table
4	Activating Compound
165	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
105	Disease/ Diagnostics
1	General Stability
1	IC50 Value
57	Inhibitors
3	kcat/KM [mM/s]
13	Ki Value [mM]
39	KM Value [mM]
16	Localization
15	Metals/Ions
15	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
33	Organism
14	Pathway
13	PDB ID
9	pH Optimum
2	pH Range
1	pH Stability
6	Protein Variants
17	Purification (Commentary)
3	Reaction
1	Reaction Type
32	Reference
32	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
154	Substrates and Products (Substrate)
11	Subunits
30	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Subunits

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Subunits on EC 6.2.1.2 - medium-chain acyl-CoA ligase

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SUBUNIT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

?

2 entries

dimer

3 entries

monomer

Bos taurus

-

1 * 65000, the enzyme exists in monomeric, dimeric and tertameric form, SDS-PAGE

676

tetramer

2 entries

additional information

3 entries

?

Bos taurus

-

x * 38000, SDS-PAGE

672

?

Penicillium chrysogenum

O74725

x * 62600, recombinant enzyme, SDS-PAGE

690837

dimer

Bos taurus

-

x * 65000, the enzyme exists in monomeric, dimeric and tertameric form, SDS-PAGE

676

dimer

Paecilomyces variotii

-

2 * 74000, SDS-PAGE

668

dimer

Paecilomyces variotii AHU 9417

-

2 * 74000, SDS-PAGE

-

tetramer

Bos taurus

-

x * 65000, the enzyme exists in monomeric, dimeric and tertameric form, SDS-PAGE

676

tetramer

Pseudomonas aeruginosa

-

4 * 37000, SDS-PAGE

669

additional information

Dictyostelium discoideum

Q54CJ4

EloA membrane topology model where the ELO consensus motifs are located at the cytosolic face of the membrane consistent with their potential role in the catalytic activity of EloA

690742

additional information

Dictyostelium discoideum AX3

-

EloA membrane topology model where the ELO consensus motifs are located at the cytosolic face of the membrane consistent with their potential role in the catalytic activity of EloA

-

additional information

Penicillium chrysogenum

O74725

enzyme structure modelling of wild-type and mutant enzymes using the crystal structure of the luciferase from firefly species Luciola cruciata as template, PDB ID 2D1S

690837