6.2.1.2: medium-chain acyl-CoA ligase
This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.2
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6.2.1.2
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desaturase
-
polyunsaturated
-
pufas
-
docosahexaenoic
-
arachidonic
-
monounsaturated
-
eicosapentaenoic
-
linoleic
-
desaturation
-
elovl5
-
unsaturated
-
lc-pufas
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acyl-coas
-
oleic
-
stearoyl-coa
-
very-long-chain
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vlcfas
-
palmitoleic
-
delta6
-
stearic
-
alpha-linolenic
-
linseed
-
gamma-linolenic
-
alpina
-
stargardt
-
mortierella
-
isochrysis
-
3-ketoacyl-coa
-
erucic
-
cis-vaccenic
-
vaccenic
-
dihomo-gamma-linolenic
-
medicine
-
stearidonic
- 6.2.1.2
-
desaturase
-
polyunsaturated
-
pufas
-
docosahexaenoic
-
arachidonic
-
monounsaturated
-
eicosapentaenoic
-
linoleic
-
desaturation
- elovl5
- unsaturated
-
lc-pufas
- acyl-coas
-
oleic
- stearoyl-coa
-
very-long-chain
-
vlcfas
-
palmitoleic
-
delta6
-
stearic
-
alpha-linolenic
-
linseed
-
gamma-linolenic
- alpina
- stargardt
- mortierella
- isochrysis
- 3-ketoacyl-coa
-
erucic
-
cis-vaccenic
-
vaccenic
-
dihomo-gamma-linolenic
- medicine
-
stearidonic
Reaction
Synonyms
Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase
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Reference on EC 6.2.1.2 - medium-chain acyl-CoA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Scaife, J.R.; Tichivangana, J.Z.
Short chain acyl-CoA synthetase in ovine rumen epithelium
Biochim. Biophys. Acta
619
445-450
1980
Ovis aries
Reijnierse, G.L.A.; Veldstra, H.; Van den Berg, C.J.
Short-chain fatty acid synthesis in brain. Subcellular localization and changes during development
Biochem. J.
152
477-484
1975
Rattus norvegicus
Reijnierse, G.L.A.; Veldstra, H.; van den Berg, C.J.
Radioassay of acetyl-CoA synthetase, propionyl-CoA synthetase and butyryl-CoA synthetase in brain
Anal. Biochem.
72
614-622
1976
Rattus norvegicus
Takao, S.; Ito, T.; Tanida, M.
Purification and kinetic properties of butyryl-CoA synthetase from Paecilomyces varioti
Agric. Biol. Chem.
51
145-152
1987
Paecilomyces variotii, Paecilomyces variotii AHU 9417
-
Shimizu, S.; Inoue, K.; Tani, Y.; Yamada, H.
Butyryl-CoA synthetase of Pseudomonas aeruginosa. Purification and characterization
Biochem. Biophys. Res. Commun.
103
1231-1237
1981
Pseudomonas aeruginosa
Reed, W.D.; Ozand, P.T.
Enzymes of L-(+)-3-hydroxybutyrate metabolism in the rat
Arch. Biochem. Biophys.
205
94-103
1980
Rattus norvegicus
Johnston, R.W.; Osmundsen, H.; Park, M.V.
Associative properties of butyryl-coenzyme A synthetase from ox liver mitochondria
Biochim. Biophys. Acta
569
70-81
1979
Bos taurus
Scholte, H.R.; Groot, P.H.E.
Organ and intracellular localization of short-chain acyl-CoA synthetase in rat and guinea-pig
Biochim. Biophys. Acta
409
283-296
1975
Cavia porcellus, Rattus norvegicus
Osmundsen, H.; Park, M.V.
Bovine serum albumin activation of ox liver butyryl-coenzyme A synthetase
Biochem. Soc. Trans.
3
327-329
1975
Bos taurus
Webster, L.T.; Gerowin, L.D.; Rakita, L.
Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria
J. Biol. Chem.
240
29-33
1965
Bos taurus
Kasuya, F.; Igarashi, K.; Fukui, M.; Nokihara, K.
Purification and characterization of a medium chain acyl-coenzyme A synthetase
Drug Metab. Dispos.
24
879-883
1996
Bos taurus
Kasuya, F.; Igarashi, K.; Fukui, M.
Participation of a medium chain acyl-CoA synthetase in glycine conjugation of the benzoic acid derivatives with the electron-donating groups
Biochem. Pharmacol.
51
805-809
1996
Bos taurus
Campbell, C.J.; Park, M.V.
The role of the available sulphydryl group in liver butyryl-coenzyme A synthetase
Int. J. Biochem.
19
539-544
1987
Bos taurus
Mao, L.F.; Millington, D.S.; Schulz, H.
Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid
J. Biol. Chem.
267
3143-3146
1992
Rattus norvegicus
Kasuya, F.; Igarashi, K.; Fukui, M.
Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids
Biochem. Pharmacol.
52
1643-1646
1996
Bos taurus
Vessey, D.A.; Kelley, M.
Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase
Biochem. J.
357
283-288
2001
Bos taurus
Kasuya, F.; Yamaoka, Y.; Igarashi, K.; Fukui, M.
Molecular specificity of a medium chain acyl-CoA synthetase for substrates and inhibitors: conformational analysis
Biochem. Pharmacol.
55
1769-1775
1998
Bos taurus
Kasuya, F.; Hiasa, M.; Kawai, Y.; Igarashi, K.; Fukui, M.
Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase
Biochem. Pharmacol.
62
363-367
2001
Mus musculus
Morsczeck, C.; Berger, S.; Plum, G.
The macrophage-induced gene (mig) of Mycobacterium avium encodes a medium-chain acyl-coenzyme A synthetase
Biochim. Biophys. Acta
1521
59-65
2001
Mycobacterium avium
Kasuya, F.; Igarashi, K.; Fukui, M.
Characterization of a renal medium chain acyl-CoA synthetase responsible for glycine conjugation in mouse kidney mitochondria
Chem. Biol. Interact.
118
233-246
1999
Mus musculus
Vessey, D.A.
Isolation and preliminary characterization of the medium-chain fatty acid:CoA ligase responsible for activation of short- and medium-chain fatty acids in colonic mucosa from swine
Dig. Dis. Sci.
46
438-442
2001
Sus scrofa
Vessey, D.A.; Lau, E.; Kelley, M.; Warren, R.S.
Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria
J. Biochem. Mol. Toxicol.
17
1-6
2003
Homo sapiens
Arabolaza, A.; Banchio, C.; Gramajo, H.
Transcriptional regulation of the macs1-fadD1 operon encoding two acyl-CoA synthases involved in the physiological differentiation of Streptomyces coelicolor
Microbiology
152
1427-1439
2006
Streptomyces coelicolor
Lindner, I.; Rubin, D.; Helwig, U.; Nitz, I.; Hampe, J.; Schreiber, S.; Schrezenmeir, J.; Doering, F.
The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population
Mol. Nutr. Food Res.
50
270-274
2006
Homo sapiens
Kasuya, F.; Tatsuki, T.; Ohta, M.; Kawai, Y.; Igarashi, K.
Purification, characterization, and mass spectrometric sequencing of a medium chain acyl-CoA synthetase from mouse liver mitochondria and comparisons with the homologs of rat and bovine
Protein Expr. Purif.
47
405-414
2006
Bos taurus, Mus musculus
Blacklock, B.J.; Kelley, D.; Patel, S.
A fatty acid elongase ELO with novel activity from Dictyostelium discoideum
Biochem. Biophys. Res. Commun.
374
226-230
2008
Dictyostelium discoideum (Q54CJ4)
Koetsier, M.J.; Jekel, P.A.; van den Berg, M.A.; Bovenberg, R.A.; Janssen, D.B.
Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum
Biochem. J.
417
467-476
2008
Penicillium chrysogenum (O74725)
Meng, Y.; Ingram-Smith, C.; Cooper, L.L.; Smith, K.S.
Characterization of an archaeal medium-chain acyl coenzyme A synthetase from Methanosarcina acetivorans
J. Bacteriol.
192
5982-5990
2010
Methanosarcina acetivorans (Q8TLW1), Methanosarcina acetivorans, Methanosarcina acetivorans DSM 2834 (Q8TLW1)
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