5.4.99.8: cycloartenol synthase

This is an abbreviated version!
For detailed information about cycloartenol synthase, go to the full flat file.

Word Map on EC 5.4.99.8

5.4.99.8

sterol

triterpene

phytosterols

lanosterol

cyclases

triterpenoids

lupeol

beta-amyrin

withanolides

dunal

soyasaponins

dammarenediol

parkeol

Reaction

Synonyms

(S)-2,3-epoxysqualene mutase, 2,3-Epoxysqualene cycloartenol-cyclase, 2,3-epoxysqualene--cycloartenol cyclase, 2,3-Epoxysqualene-cycloartenol cyclase, 2,3-Oxidosqualene cycloartenol cyclase, 2,3-Oxidosqualene-cycloartenol cyclase, 2,3-Oxidosqualene:cycloartenol cyclase, ACX, AtCAS1, AthCAS1, CaCYS, CAS, CAS1, Cyclase, 2,3-oxidosqualene-cycloartenol, cycloartenol synthase, cycloartenol synthase 1, LdCAS, NbCAS, NtCAS, OSC, OSC/CS, Oxidosqualene cyclase, PNX, PtCAS1, PtCAS2, SgCAS, WsCAS

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.99 Transferring other groups

5.4.99.8 cycloartenol synthase

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Results	in table
7	Activating Compound
72	AA Sequence
1	CAS Registry Number
26	Cloned(Commentary)
8	Expression
27	General Information
21	Inhibitors
5	KM Value [mM]
10	Localization
1	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
5	Pathway
3	pH Optimum
3	pI Value
29	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
45	Reference
49	Source Tissue
4	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
8	Subunits
43	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 5.4.99.8 - cycloartenol synthase

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2-Aza-2,3-dihydro-squalene-N-oxide

Rubus plicatus

3631

2-Aza-2,3-dihydrosqualene

3 entries

2-hydroxyethyl jasmonate

Panax notoginseng

A8UHA2

downregulation of gene expression at 200 mM, diethydithiocarbamate depresses the down-regulation of CAS gene expression by 2-hydroxyethyl jasmonate

694930

3beta-(2-Diethylaminoethoxy)androstenone

8-Azadecalin

Carbenium ion intermediate analogue inhibitors

KCl

methyl jasmonate

inhibits CaCYS transcription

661372

Monocyclic 4-hydroxypiperidine

Zea mays

3624

N-Lauryl-N-dimethylamino-N-oxide

Rubus plicatus

3631

N-[(1,5,9)-Trimethyl-decyl]-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol

NEM

p-chloromercuribenzene sulfonic acid

Pisum sativum

3627

p-hydroxymercuribenzoate

Ochromonas malhamensis

3619

Ro 48-8071

Nicotiana tabacum

A0A0A1ER86

a potent inhibitor of oxidosqualene cyclization, the site of RO 48-8071 inhibition is CAS

748519

sodium deoxycholate

Ochromonas malhamensis

stimulates at low concentrations, optimal activation at 0.1%. Inhibition at levels greater than 0.5%

3619

additional information

3 entries