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5.4.99.8: cycloartenol synthase

This is an abbreviated version!
For detailed information about cycloartenol synthase, go to the full flat file.

Word Map on EC 5.4.99.8

Reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene
=
Cycloartenol

Synonyms

(S)-2,3-epoxysqualene mutase, 2,3-Epoxysqualene cycloartenol-cyclase, 2,3-epoxysqualene--cycloartenol cyclase, 2,3-Epoxysqualene-cycloartenol cyclase, 2,3-Oxidosqualene cycloartenol cyclase, 2,3-Oxidosqualene-cycloartenol cyclase, 2,3-Oxidosqualene:cycloartenol cyclase, ACX, AtCAS1, AthCAS1, CaCYS, CAS, CAS1, Cyclase, 2,3-oxidosqualene-cycloartenol, cycloartenol synthase, cycloartenol synthase 1, LdCAS, NbCAS, NtCAS, OSC, OSC/CS, Oxidosqualene cyclase, PNX, PtCAS1, PtCAS2, SgCAS, WsCAS

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.8 cycloartenol synthase

Expression

Expression on EC 5.4.99.8 - cycloartenol synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
inhibitor RO 48-8071 leads to downregulation of gene CAS in cells. CAS gene expression is partially blocked by using an inducible artificial microRNA with limited effectiveness
plant derived and microbe derived elicitors altered WsOSCs expression pattern both at mRNA and protein level which corresponded with the change in the accumulation of three key withanolides namely withanolide A, withanone, and withaferin A, overview
salicylic acid at 2 mM and 5 mM and methyl jasmonate at 0.2-0.5 mM enhance the WsCAS transcript expression levels 1-2fold. The overall content of withanolide is increased by 1-2fold at 2mM salicylate and by methyl jasmonate at 0.2-0.5 mM. Direct correlation between the WsCAS expression and accumulation of withanolide in treated seedlings under elicitor treatment
the cycloartenol synthase gene in hairy root cultures elicited by 0.1 mM methyl jasmonate treatment decreases slightly
the isozyme PtCAS1 is induced 1.5fold by methyl jasmonate. The transcript patterns of the two PtCAS isozyme seedling genes after methyl jasmonate treatment are similar
the isozyme PtCAS2 is induced 2.0fold by methyl jasmonate. The transcript patterns of the two PtCAS isozyme seedling genes after methyl jasmonate treatment are similar
wounding, as well as cold or heat treatments downregulate the enzyme expression and winthanolides production in seedlings. Cold, heat and wounding reduce the WsCAS expression levels up to 0.25, 0.51, and 0.59fold respectively. The overall content of withanolide is reduced. Direct correlation between the WsCAS expression and accumulation of withanolide in treated seedlings