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5.4.99.18: 5-(carboxyamino)imidazole ribonucleotide mutase

This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide mutase, go to the full flat file.

Word Map on EC 5.4.99.18

Reaction

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
=
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

Synonyms

BaPurE, N5-CAIR mutase, N5-carboxy-amino-imidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide synthetase, PurE

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.18 5-(carboxyamino)imidazole ribonucleotide mutase

Inhibitors

Inhibitors on EC 5.4.99.18 - 5-(carboxyamino)imidazole ribonucleotide mutase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-bromo-5-ethoxy-4-methoxyphenyl)methanol
A0A1S0QXP6
-
(2-ethoxyphenyl)(morpholino)methanethione
A0A1S0QXP6
-
(5-(2-chlorophenyl)isoxazol-3-yl)methanamine
A0A1S0QXP6
-
2-methyl-N-(5-methylthiazol-2-yl)furan-3-carboxamide
A0A1S0QXP6
-
3,4-dihydroxybenzoic acid
A0A1S0QXP6
a scaffold hit from library screening
3-(4-methoxyphenyl)-1H-pyrazol-5-amine
A0A1S0QXP6
-
3-chloro-N-(5-(2,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)benzamide
19% inhibition at 0.010 mM
3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine
A0A1S0QXP6
-
4,5-dichlorobenzene-1,2-diol
A0A1S0QXP6
-
4-benzoyl-N-(5-(2,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide
13% inhibition at 0.010 mM
4-Nitro-5-aminoimidazole ribonucleotide
NAIR
5-ethyl-N-(1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide
A0A1S0QXP6
49% inhibition at 0.025 mM
5-fluoro-1H-indole-2-carboxylic acid
A0A1S0QXP6
a scaffold hit from library screening
6-methoxyquinolin-3-amine
A0A1S0QXP6
-
indoline-1-carbothioamide
A0A1S0QXP6
-
isoquinolin-1-amine
A0A1S0QXP6
a scaffold hit from library screening
N-(3-fluorophenyl)-5-methylisoxazole-3-carboxamide
A0A1S0QXP6
-
N-(p-tolyl)-1,2,3,4-thiatriazol-5-amine
A0A1S0QXP6
36% inhibition at 0.1 mM
pyridin-4-yl(p-tolyl)methanamine
A0A1S0QXP6
-
additional information
high-throughput screening of compounds binding to Bacillus anthracis PurE. A a low ionic strength buffer condition is used to accentuate the thermal shift stabilization induced by compound binding to Bacillus anthracis PurE. Computational ligand docking to the active site. Determination of inhibitory compounds for inhibition of BaPurE activity and for cytotoxicity against Bacillus anthracis (DELTAANR strain), Escherichia coli (BW25113 strain, wild-type and DELTATolC), Francisella tularensis, Staphylococcus aureus (both methicillin susceptible and methicillin-resistant strains) and Yersinia pestis. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, overview
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