5.4.99.18: 5-(carboxyamino)imidazole ribonucleotide mutase
This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide mutase, go to the full flat file.
Word Map on EC 5.4.99.18
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5.4.99.18
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purine
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4-carboxy-5-aminoimidazole
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5-aminoimidazole
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aceti
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acetobacter
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acidophilic
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mgadp
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amide
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co2
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bicarbonate
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ph-rate
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soaked
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carboxyphosphate
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drug development
- 5.4.99.18
- purine
-
4-carboxy-5-aminoimidazole
- 5-aminoimidazole
- aceti
-
acetobacter
-
acidophilic
- mgadp
- amide
- co2
- bicarbonate
-
ph-rate
-
soaked
- carboxyphosphate
- drug development
Reaction
Synonyms
BaPurE, N5-CAIR mutase, N5-carboxy-amino-imidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide synthetase, PurE
ECTree
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Inhibitors
Inhibitors on EC 5.4.99.18 - 5-(carboxyamino)imidazole ribonucleotide mutase
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3,4-dihydroxybenzoic acid
A0A1S0QXP6
a scaffold hit from library screening
3-chloro-N-(5-(2,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)benzamide
19% inhibition at 0.010 mM
4-benzoyl-N-(5-(2,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide
13% inhibition at 0.010 mM
5-ethyl-N-(1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide
A0A1S0QXP6
49% inhibition at 0.025 mM
5-fluoro-1H-indole-2-carboxylic acid
A0A1S0QXP6
a scaffold hit from library screening
N-(p-tolyl)-1,2,3,4-thiatriazol-5-amine
A0A1S0QXP6
36% inhibition at 0.1 mM
additional information
high-throughput screening of compounds binding to Bacillus anthracis PurE. A a low ionic strength buffer condition is used to accentuate the thermal shift stabilization induced by compound binding to Bacillus anthracis PurE. Computational ligand docking to the active site. Determination of inhibitory compounds for inhibition of BaPurE activity and for cytotoxicity against Bacillus anthracis (DELTAANR strain), Escherichia coli (BW25113 strain, wild-type and DELTATolC), Francisella tularensis, Staphylococcus aureus (both methicillin susceptible and methicillin-resistant strains) and Yersinia pestis. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, overview
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