5.4.99.18: 5-(carboxyamino)imidazole ribonucleotide mutase

This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide mutase, go to the full flat file.

Reaction

Synonyms

BaPurE, N5-CAIR mutase, N5-carboxy-amino-imidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide synthetase, PurE

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.99 Transferring other groups

                5.4.99.18 5-(carboxyamino)imidazole ribonucleotide mutase

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Results	in table
36478	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
7	Crystallization (Commentary)
3	General Information
22	Inhibitors
9	KM Value [mM]
1	Metals/Ions
8	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
21	Organism
7	Pathway
36	PDB ID
3	pH Optimum
1	pH Stability
17	Protein Variants
5	Purification (Commentary)
3	Reaction
17	Reference
2	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
3	Subunits
23	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.4.99.18 - 5-(carboxyamino)imidazole ribonucleotide mutase

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SYSTEMATIC NAME

IUBMB Comments

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase

In eubacteria, fungi and plants, this enzyme, along with EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates [6]. In the absence of EC 6.3.2.6, phosphoribosylaminoimidazolesuccinocarboxamide synthase, the reaction is reversible [3]. The substrate is readily converted into 5-amino-1-(5-phospho-D-ribosyl)imidazole by non-enzymic decarboxylation [3].