5.4.99.18: 5-(carboxyamino)imidazole ribonucleotide mutase
This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide mutase, go to the full flat file.
Word Map on EC 5.4.99.18
-
5.4.99.18
-
purine
-
4-carboxy-5-aminoimidazole
-
5-aminoimidazole
-
aceti
-
acetobacter
-
acidophilic
-
mgadp
-
amide
-
co2
-
bicarbonate
-
ph-rate
-
soaked
-
carboxyphosphate
-
drug development
- 5.4.99.18
- purine
-
4-carboxy-5-aminoimidazole
- 5-aminoimidazole
- aceti
-
acetobacter
-
acidophilic
- mgadp
- amide
- co2
- bicarbonate
-
ph-rate
-
soaked
- carboxyphosphate
- drug development
Reaction
Synonyms
BaPurE, N5-CAIR mutase, N5-carboxy-amino-imidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide mutase, N5-carboxyaminoimidazole ribonucleotide synthetase, PurE
ECTree
Advanced search results
Reaction
Reaction on EC 5.4.99.18 - 5-(carboxyamino)imidazole ribonucleotide mutase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
-
-
-
-
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
common, buried carboxylate or CO2 binding site for substrate and product in a hydrophobic pocket, in which the carboxylate or CO2 interacts with backbone amides. The carboxylate orients the substrate for proton transfer from His45 to 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole to form an enzyme-bound aminoimidazole ribonucleotide and CO2 intermediate. subsequent movement of the aminoimidazole moiety reorients it for addition of CO2 at C4 to generate iso-5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. H5 is now in a position to remove a C4 proton to produce 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
H89 is not essential and does not function as part of a proton relay system. For synthesis of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the carboxylate moiety is positioned in a small pocket proposed to facilitate nucleotide decarboxylation. In the reverse direction, enzyme favors protonation of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate C4