5.2.1.1: maleate isomerase

This is an abbreviated version!
For detailed information about maleate isomerase, go to the full flat file.

Reaction

Synonyms

Isomerase, maleate, MaiA, maleate cis-trans isomerase, Pp-Iso

ECTree

     5 Isomerases

         5.2 cis-trans-Isomerases

             5.2.1 cis-trans Isomerases (only sub-subclass identified to date)

                5.2.1.1 maleate isomerase

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Results	in table
6	Activating Compound
2603	AA Sequence
1	Application
1	CAS Registry Number
4	Cloned(Commentary)
3	Crystallization (Commentary)
4	General Information
1	General Stability
36	Inhibitors
5	kcat/KM [mM/s]
1	Ki Value [mM]
9	KM Value [mM]
3	Metals/Ions
9	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
27	Organism
1	Oxidation Stability
11	Pathway
8	PDB ID
9	pH Optimum
8	pH Range
4	pH Stability
24	Protein Variants
6	Purification (Commentary)
1	Reaction
3	Reaction Type
23	Reference
4	Specific Activity [micromol/min/mg]
2	Storage Stability
33	Substrates and Products (Substrate)
8	Subunits
8	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
5	Temperature Range [°C]
13	Temperature Stability [°C]
7	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 5.2.1.1 - maleate isomerase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Bromoacetate

2 entries

bromomaleate

Nocardia farcinica

Q5YXQ1

weak inhibitor

715258

Cu2+

Alcaligenes faecalis

-

-

2453

cyanide

2 entries

deoxycholate

Pseudomonas sp.

-

-

2451

EDTA

3 entries

Fe2+

Alcaligenes faecalis

-

-

2451

H2O2

2 entries

Hg2+

Alcaligenes faecalis

-

-

2451, 2453

iodoacetamide

2 entries

iodoacetate

3 entries

N-bromosuccinimide

2 entries

N-Chlorosuccinimide

2 entries

NaCN

Pseudomonas sp.

-

0.6 mM, 20% inhibition

2451

NaF

Pseudomonas sp.

-

0.6-3 mM, 18-45% inhibition

2451

p-chloromercuriphenylsulfonate

Alcaligenes faecalis

-

-

2456

p-Substituted mercuribenzoate

2 entries

p-toluenesulfonchloramide

Serratia marcescens

-

1 mM, complete inhibition

650608

PCMB

2 entries

Semicarbazide

Alcaligenes faecalis

-

1 mM, weak inhibition

2451

Sodium periodate

2 entries

Bromoacetate

Pseudomonas fluorescens

-

-

2451, 2454

Bromoacetate

Pseudomonas sp.

-

-

2451

cyanide

Alcaligenes faecalis

-

1 mM, weak inhibition

2451

cyanide

Alcaligenes faecalis

-

KCN, 1 mM, 20% inhibition

2453

EDTA

Alcaligenes faecalis

-

-

2451

EDTA

Alcaligenes faecalis

-

1 mM, 7% inhibition

2453

EDTA

Pseudomonas sp.

-

0.1 mM, 20% inhibition

2451

H2O2

Alcaligenes faecalis

-

-

2456

H2O2

Serratia marcescens

-

1 mM, complete inhibition, Met201 is one of the targeted sites for the inactivation by chemical oxidation

650608

iodoacetamide

Alcaligenes faecalis

-

-

2456

iodoacetamide

Serratia marcescens

-

1 mM, 72% inhibition

650608

iodoacetate

Alcaligenes faecalis

-

-

2451

iodoacetate

Alcaligenes faecalis

-

1 mM 73% inhibition

2453

iodoacetate

Pseudomonas sp.

-

0.01 mM, complete inhibition

2451

N-bromosuccinimide

Alcaligenes faecalis

-

1 mM, weak inhibition

2451

N-bromosuccinimide

Serratia marcescens

-

1 mM, complete inhibition

650608

N-Chlorosuccinimide

Alcaligenes faecalis

-

-

2456

N-Chlorosuccinimide

Serratia marcescens

-

1 mM, complete inhibition

650608

p-Substituted mercuribenzoate

Alcaligenes faecalis

-

-

2451

p-Substituted mercuribenzoate

Pseudomonas sp.

-

0.01 mM, complete inhibition

2451

PCMB

Alcaligenes faecalis

-

0.1 mM, complete inhibition; inhibition is overcome by the addition of sulfhydryl compounds

2453

PCMB

Serratia marcescens

-

0.1 mM, complete inhibition

650608

Sodium periodate

Alcaligenes faecalis

-

-

2451

Sodium periodate

Alcaligenes faecalis

-

1 mM, complete inhibition

2453