5.1.1.17: isopenicillin-N epimerase

This is an abbreviated version!
For detailed information about isopenicillin-N epimerase, go to the full flat file.

Word Map on EC 5.1.1.17

5.1.1.17

cephalosporin

acremonium

chrysogenum

beta-lactam

clavuligerus

epimerization

deacetoxycephalosporin

cefef

pyridoxal

pcbab

deacetylcephalosporin

cephamycins

expandase

acyltransferase

pende

untransformed

alpha-aminoadipic

lactamdurans

daocs

biotechnology

synthesis

medicine

Reaction

Synonyms

cefD2, IPN epimerase, isopenecillin N-CoA epimerase, isopenicillin N epimerase, isopenicillin N-CoA epimerase, PenN epimerase

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.17 isopenicillin-N epimerase

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Results	in table
500	AA Sequence
5	Application
1	CAS Registry Number
3	Cloned(Commentary)
5	Cofactor
2	Expression
2	General Stability
21	Inhibitors
6	KM Value [mM]
6	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
20	Organism
4	Pathway
3	pH Optimum
1	pH Range
2	pH Stability
4	Purification (Commentary)
2	Reaction
5	Reaction Type
17	Reference
2	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
28	Substrates and Products (Substrate)
3	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 5.1.1.17 - isopenicillin-N epimerase

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4-chloromercuribenzoate

2 entries

ammonium sulfate

Amycolatopsis lactamdurans

100 mM, 47% inhibition

492261

Cu2+

Amycolatopsis lactamdurans

1 mM, complete inhibition

492261

D-cycloserine

Streptomyces clavuligerus

1 mM, 23% inhibition

492260

FAD

Streptomyces clavuligerus

0.5 mM, 80% inhibition

492260

Fe2+

Amycolatopsis lactamdurans

0.135 mM, complete inhibition

492261

fluorescamine

Streptomyces clavuligerus

inactivation at molar ratios higher than 2

492260

Hg2+

Amycolatopsis lactamdurans

1 mM, complete inhibition

492261

hydroxylamine

2 entries

I-

Amycolatopsis lactamdurans

1 mM, 27% inhibition

492261

iodoacetamide

2 entries

Iproniazid

2 entries

isoniazid

Streptomyces clavuligerus

1 mM, 23% inhibition

492260

N-ethylmaleimide

2 entries

Phenylglyoxal

Streptomyces clavuligerus

1 mM, 33% inhibition

492260

Zn2+

Amycolatopsis lactamdurans

1 mM, 50% inhibition

492261