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4.99.1.4: sirohydrochlorin ferrochelatase

This is an abbreviated version!
For detailed information about sirohydrochlorin ferrochelatase, go to the full flat file.

Word Map on EC 4.99.1.4

Reaction

siroheme
+ 2 H+ =
sirohydrochlorin
 +
Fe2+

Synonyms

CbiX, CysG, Met8p, More, SirB, sirohydrochlorin ferrochelatase, sirohydrochlorin-ferrochelatase

ECTree

     4 Lyases
         4.99 Other lyases
             4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses
                4.99.1.4 sirohydrochlorin ferrochelatase

Specific Activity

Specific Activity on EC 4.99.1.4 - sirohydrochlorin ferrochelatase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0034
-
pH 8, cobaltochelation of precorrin-2
0.0054
-
isolated recombinant enzyme, with ferrous iron as substrate
0.0138
-
S128D mutant CysG, cobalt chelation of sirohydrochlorin
0.0311
wild-type Met8p
0.0485
-
isolated recombinant enzyme, with cobalt as substrate
0.0656
-
wild-type CysG, cobalt chelation of sirohydrochlorin
0.243
-
S128A mutant CysG, cobalt chelation of sirohydrochlorin
0.337
-
pH 8, cobaltochelation of sirohydrochlorin
33.25
-
mutant enzyme C199A, in 20 mM Tris/HCl (pH 8.0) and 10 mM NaCl, at 23°C
36.08
-
mutant enzyme C213A, in 20 mM Tris/HCl (pH 8.0) and 10 mM NaCl, at 23°C
38.5
-
wild type enzyme, in 20 mM Tris/HCl (pH 8.0) and 10 mM NaCl, at 23°C
43
-
mutant enzyme C219A, in 20 mM Tris/HCl (pH 8.0) and 10 mM NaCl, at 23°C
44.67
-
mutant enzyme C135A, in 20 mM Tris/HCl (pH 8.0) and 10 mM NaCl, at 23°C
55.17
-
mutant enzyme C210A, in 20 mM Tris/HCl (pH 8.0) and 10 mM NaCl, at 23°C
additional information