4.99.1.4: sirohydrochlorin ferrochelatase

This is an abbreviated version!
For detailed information about sirohydrochlorin ferrochelatase, go to the full flat file.

Reaction

Synonyms

CbiX, CysG, Met8p, More, SirB, sirohydrochlorin ferrochelatase, sirohydrochlorin-ferrochelatase

ECTree

     4 Lyases

         4.99 Other lyases

             4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses

                4.99.1.4 sirohydrochlorin ferrochelatase

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Results	in table
6995	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
1	Expression
2	Inhibitors
1	KM Value [mM]
4	Localization
3	Metals/Ions
4	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
14	Organism
6	Pathway
30	PDB ID
2	pH Optimum
1	Posttranslational Modification
12	Protein Variants
6	Purification (Commentary)
2	Reaction
11	Reference
4	Source Tissue
15	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
7	Subunits
19	Synonyms
1	Systematic Name

Engineering

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Engineering on EC 4.99.1.4 - sirohydrochlorin ferrochelatase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

C135A

Arabidopsis thaliana

-

the mutant shows increased specific activity compared to the wild type enzyme

729160

C199A

Arabidopsis thaliana

-

the mutant shows reduced specific activity compared to the wild type enzyme

729160

C210A

Arabidopsis thaliana

-

the mutant shows increased specific activity compared to the wild type enzyme

729160

C213A

Arabidopsis thaliana

-

the mutant shows reduced specific activity compared to the wild type enzyme

729160

C219A

Arabidopsis thaliana

-

the mutant shows increased specific activity compared to the wild type enzyme

729160

D141A

2 entries

G22D

2 entries

H237A

Saccharomyces cerevisiae

P15807

mutant of bifunctional Met8p is active as both dehydrogenase and ferrochelatase

644283

S128A

Salmonella enterica

-

mutant has higher cobalt chelatase activity than wild-type CysG with sirohydrochlorin as substrate

653297

S128D

Salmonella enterica

-

mutant has lower cobalt chelatase activity than wild-type CysG with sirohydrochlorin as substrate

653297

D141A

Saccharomyces cerevisiae

P15807

mutant of bifunctional Met8p is completely inactive as both dehydrogenase and ferrochelatase

644283

D141A

Saccharomyces cerevisiae

-

mutant of bifunctional Met8p is devoid of both dehydrogenase and ferrochelatase activities

649817

G22D

Saccharomyces cerevisiae

P15807

mutant of bifunctional Met8p is completely inactive as dehydrogenase, but functions as ferrochelatase

644283

G22D

Saccharomyces cerevisiae

-

mutant of bifunctional Met8p is completely inactive as NAD+-dependent dehydrogenase, but functions as ferrochelatase

649817