4.99.1.4: sirohydrochlorin ferrochelatase

This is an abbreviated version!
For detailed information about sirohydrochlorin ferrochelatase, go to the full flat file.

Reaction

Synonyms

CbiX, CysG, Met8p, More, SirB, sirohydrochlorin ferrochelatase, sirohydrochlorin-ferrochelatase

ECTree

     4 Lyases

         4.99 Other lyases

             4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses

                4.99.1.4 sirohydrochlorin ferrochelatase

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Results	in table
6995	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
1	Expression
2	Inhibitors
1	KM Value [mM]
4	Localization
3	Metals/Ions
4	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
14	Organism
6	Pathway
30	PDB ID
2	pH Optimum
1	Posttranslational Modification
12	Protein Variants
6	Purification (Commentary)
2	Reaction
11	Reference
4	Source Tissue
15	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
7	Subunits
19	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 4.99.1.4 - sirohydrochlorin ferrochelatase

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SYSTEMATIC NAME

IUBMB Comments

siroheme ferro-lyase (sirohydrochlorin-forming)

This enzyme catalyses the third of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction.