4.6.1.17: cyclic pyranopterin monophosphate synthase

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For detailed information about cyclic pyranopterin monophosphate synthase, go to the full flat file.

Reaction

Synonyms

cnx3, cyclic pyranopterin monophosphate synthase accessory protein, EC 4.1.99.18, MoaC, MoaC2, Moco-biosynthesis protein, MOCS1B, molybdenum cofactor biosynthesis protein C, ST0472

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.17 cyclic pyranopterin monophosphate synthase

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2	Activating Compound
31451	AA Sequence
1	Cloned(Commentary)
4	Crystallization (Commentary)
5	Disease/ Diagnostics
1	Expression
3	General Information
1	Inhibitors
6	KM Value [mM]
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
102	Organism
3	Pathway
1	PDB ID
8	Protein Variants
2	Purification (Commentary)
4	Reaction
13	Reference
14	Substrates and Products (Substrate)
12	Subunits
23	Synonyms
1	Systematic Name
6	Turnover Number [1/s]

Expression

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Expression on EC 4.6.1.17 - cyclic pyranopterin monophosphate synthase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

the first two enzymes of the molybdopterin biosynthesis pathway are encoded by the MOCS1 locus in humans. Isoform MOCS1A and isoform MOCS1B form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate. They are encoded by an apparently bicistronic MOCS1AMOCS1B transcript which bypasses the normal termination nonsense codon of MOCS1A resulting in fusion of the MOCS1A and MOCS1B open reading frames. The bicistronic form of MOCS1 mRNA is likely to only produce MOCS1A protein and suggests that MOCS1B is translated only as a fusion with MOCS1A

Homo sapiens

Q9NZB8

739638