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4.6.1.17: cyclic pyranopterin monophosphate synthase

This is an abbreviated version!
For detailed information about cyclic pyranopterin monophosphate synthase, go to the full flat file.

Reaction

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate
=
cyclic pyranopterin phosphate
+
diphosphate

Synonyms

cnx3, cyclic pyranopterin monophosphate synthase accessory protein, EC 4.1.99.18, MoaC, MoaC2, Moco-biosynthesis protein, MOCS1B, molybdenum cofactor biosynthesis protein C, ST0472

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.17 cyclic pyranopterin monophosphate synthase

Systematic Name

Systematic Name on EC 4.6.1.17 - cyclic pyranopterin monophosphate synthase

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SYSTEMATIC NAME
IUBMB Comments
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate lyase (cyclic pyranopterin phosphate-forming)
The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaC and Cnx3, respectively. In mammals the reaction is catalysed by the MOCS1B domain of the bifuctional MOCS1 protein, which also catalyses EC 4.1.99.22, GTP 3',8-cyclase.