4.4.1.17: Holocytochrome-c synthase

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For detailed information about Holocytochrome-c synthase, go to the full flat file.

Reaction

Synonyms

CCHL, ccsA1, cyc2p, CYC3, cytochrome c heme lyase, Cytochrome c heme-lyase, Cytochrome c synthase, HCC synthase, HCCH, HCCS, heme lyase, holocytochrome c synthase, Holocytochrome c synthetase, Holocytochrome c-type synthase, Holocytochrome-C synthase, Holocytochrome-C-type synthase, Synthetase, holocytochrome c, System III

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.17 Holocytochrome-c synthase

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Results	in table
6	Activating Compound
4729	AA Sequence
4	Application
1	CAS Registry Number
18	Cloned(Commentary)
2	Cofactor
505	Disease/ Diagnostics
8	General Information
4	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
26	Localization
4	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
35	Organism
4	Pathway
1	pH Optimum
1	pH Range
39	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
34	Reference
3	Source Tissue
3	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
2	Subunits
32	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 4.4.1.17 - Holocytochrome-c synthase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Deuterohemin

Neurospora crassa

-

r; reversible inhibition

94057

hemin

Neurospora crassa

-

at concentrations higher than 0.002 mM; at higher concentrations

94057

Holocytochrome c

Saccharomyces cerevisiae

-

competitive inhibition

651895

N-ethylmaleimide

Neurospora crassa

-

kinetics, in vivo; pretreatment of reticulocyte lysates with N-ethylmaleimide results in nearly complete inactivation

94057