4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
This is an abbreviated version!
For detailed information about pyridoxal 5'-phosphate synthase (glutamine hydrolysing), go to the full flat file.
Word Map on EC 4.3.3.6
-
4.3.3.6
-
glutaminase
-
ammonia
-
amidotransferase
-
heteromeric
-
deoxyxylulose
-
vitamer
-
pentose
-
falciparum
-
ribulose
-
malaria
-
eubacteria
-
dodecameric
-
imine
-
oxyanion
-
l-glutamine
-
triose
-
plasmodial
-
hexameric
-
drug development
- 4.3.3.6
- glutaminase
- ammonia
-
amidotransferase
-
heteromeric
- deoxyxylulose
-
vitamer
- pentose
- falciparum
- ribulose
- malaria
- eubacteria
-
dodecameric
- imine
-
oxyanion
- l-glutamine
- triose
-
plasmodial
-
hexameric
- drug development
Reaction
Synonyms
Pdx1, PDX2, PdxS, Ph1355, PLP synthase, PLP-synthase complex, PLPS, pyridoxal 5'-phosphate synthase, pyridoxal 5-phosphate synthase, pyridoxal 5-phosphate synthase Snz1, pyridoxal biosynthesis lyase, pyridoxal biosynthesis lyase PdxS, Rv2606c, Snz1
ECTree
Advanced search results
General Information
General Information on EC 4.3.3.6 - pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
metabolism
physiological function
additional information
-
deletion of the pdxST genes in Corynebacterium glutamicum NJ0898 results in vitamin B6 auxotrophy, which is restored by external pyridoxal, pyridoxal 5'-phosphate or pyridoxamine
malfunction
a btrC2 disruptant shows deficiency in growth and antibiotic production, and the addition of pyridoxal to the medium restores growth and short-term antibiotics production
malfunction
the disruption of the PdxS gene generates a vitamin B6 auxotrophic Mycobacterium tuberculosis mutant
malfunction
-
deletion of the pdxST genes in Corynebacterium glutamicum NJ0898 results in vitamin B6 auxotrophy, which is restored by external pyridoxal, pyridoxal 5'-phosphate or pyridoxamine
-
malfunction
Niallia circulans SANK 72073
-
a btrC2 disruptant shows deficiency in growth and antibiotic production, and the addition of pyridoxal to the medium restores growth and short-term antibiotics production
-
malfunction
-
the disruption of the PdxS gene generates a vitamin B6 auxotrophic Mycobacterium tuberculosis mutant
-
the organism synthesizes pyridoxal 5'-phosphate via the deoxyxylulose 5-phosphate (DXP)-dependent pathway
metabolism
-
the organism synthesizes pyridoxal 5'-phosphate via the deoxyxylulose 5-phosphate (DXP)-dependent pathway
-
vitamin B6 biosynthesis is essential for the survival and virulence of Mycobacterium tuberculosis
physiological function
-
vitamin B6 biosynthesis is essential for the survival and virulence of Mycobacterium tuberculosis
-
-
proteins PdxS and PdxT interact physically and form the PLP synthase, PdxT is a glutamine amidotransferase subunit that donates an amido group from glutamine to the intermediate of the enzyme reaction
additional information
the overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, is quite similar to those of other PdxS proteins. Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as pyridoxal biosynthesis lyase and glutamine amidotransferase, respectively
additional information
-
the overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, is quite similar to those of other PdxS proteins. Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as pyridoxal biosynthesis lyase and glutamine amidotransferase, respectively
additional information
-
the overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, is quite similar to those of other PdxS proteins. Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as pyridoxal biosynthesis lyase and glutamine amidotransferase, respectively
-