Information on EC 4.3.3.6 - pyridoxal 5'-phosphate synthase (glutamine hydrolysing)

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
4.3.3.6
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RECOMMENDED NAME
GeneOntology No.
pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
show the reaction diagram
overall reaction
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D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate
show the reaction diagram
(1b)
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L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
(1a)
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PATHWAY
KEGG Link
MetaCyc Link
pyridoxal 5'-phosphate biosynthesis II
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Vitamin B6 metabolism
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SYSTEMATIC NAME
IUBMB Comments
D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5'-phosphate-lyase
The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. The enzyme complex is found in aerobic bacteria, archaea, fungi and plants.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Pdx1
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pyridoxal 5'-phosphate synthase subunit
Pdx1
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pyridoxal 5'-phosphate synthase complex consits of Pdx1 and Pdx2
PDX2
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glutaminase subunit
PdxS
O59080
PdxS catalyses the condensation of ribulose 5-phosphate, glyceraldehyde 3-phosphate and ammonia, while glutamine amidotransferase (PdxT) catalyses the production of ammonia from glutamine. PdxS and PdxT form a complex
PdxS
Pyrococcus horikoshii OT-3
O59080
; PdxS catalyses the condensation of ribulose 5-phosphate, glyceraldehyde 3-phosphate and ammonia, while glutamine amidotransferase (PdxT) catalyses the production of ammonia from glutamine. PdxS and PdxT form a complex
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Ph1355
O59080
gene name
Ph1355
Pyrococcus horikoshii OT-3
O59080
gene name
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PLP synthase
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PLP synthase
P37527 and P37528
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PLP-synthase complex
Q4Z0E8
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PLP-synthase complex
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pyridoxal 5'-phosphate synthase
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pyridoxal 5-phosphate synthase
C6KT50
complex of Pdx1 and Pdx2
pyridoxal 5-phosphate synthase Snz1
Q03148
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pyridoxal biosynthesis lyase
O59080
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pyridoxal biosynthesis lyase
Pyrococcus horikoshii OT-3
O59080
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pyridoxal biosynthesis lyase PdxS
O59080
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pyridoxal biosynthesis lyase PdxS
Pyrococcus horikoshii OT-3
O59080
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
P37527: pyridoxal 5'-phosphate synthase subunit Pdx1 (pdxS), and P37528: glutaminase subunit Pdx2 (PdxT)
P37527 and P37528
SwissProt
Manually annotated by BRENDA team
Pdx2, glutaminase subunit
SwissProt
Manually annotated by BRENDA team
Corynebacterium glutamicum NJ0898
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Manually annotated by BRENDA team
Pyrococcus horikoshii OT-3
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
malfunction
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deletion of the pdxST genes in Corynebacterium glutamicum NJ0898 results in vitamin B6 auxotrophy, which is restored by external pyridoxal, pyridoxal 5'-phosphate or pyridoxamine
malfunction
Corynebacterium glutamicum NJ0898
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deletion of the pdxST genes in Corynebacterium glutamicum NJ0898 results in vitamin B6 auxotrophy, which is restored by external pyridoxal, pyridoxal 5'-phosphate or pyridoxamine
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EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression of pdxS and pdxT is significantly reduced in the presence of pyridoxal or pyridoxal 5'-phosphate, whereas supplementing with pyridoxamine or pyridoxine shows no effect on pdxST expression
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the transcription regulator PdxR controls the biosynthesis of pyridoxal or pyridoxal 5'-phosphate in Corynebacterium glutamicum by activating the expression of the pyridoxal or pyridoxal 5'-phosphate synthase genes pdxST
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expression of pdxS and pdxT is significantly reduced in the presence of pyridoxal or pyridoxal 5'-phosphate, whereas supplementing with pyridoxamine or pyridoxine shows no effect on pdxST expression
Corynebacterium glutamicum NJ0898
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the transcription regulator PdxR controls the biosynthesis of pyridoxal or pyridoxal 5'-phosphate in Corynebacterium glutamicum by activating the expression of the pyridoxal or pyridoxal 5'-phosphate synthase genes pdxST
Corynebacterium glutamicum NJ0898
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