4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolysing)

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For detailed information about pyridoxal 5'-phosphate synthase (glutamine hydrolysing), go to the full flat file.

Word Map on EC 4.3.3.6

4.3.3.6

glutaminase

ammonia

amidotransferase

heteromeric

deoxyxylulose

vitamer

pentose

falciparum

ribulose

malaria

eubacteria

dodecameric

imine

oxyanion

l-glutamine

triose

plasmodial

hexameric

drug development

Reaction

+ 3 H2O +

Synonyms

Pdx1, PDX2, PdxS, Ph1355, PLP synthase, PLP-synthase complex, PLPS, pyridoxal 5'-phosphate synthase, pyridoxal 5-phosphate synthase, pyridoxal 5-phosphate synthase Snz1, pyridoxal biosynthesis lyase, pyridoxal biosynthesis lyase PdxS, Rv2606c, Snz1

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.3 Amine-lyases

4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)

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Results	in table
1	Activating Compound
26237	AA Sequence
2	Application
19	Cloned(Commentary)
10	Crystallization (Commentary)
4	Expression
13	General Information
5	IC50 Value
6	Inhibitors
31	kcat/KM [mM/s]
35	KM Value [mM]
2	Metals/Ions
5	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
31	Organism
5	Pathway
64	PDB ID
2	pH Optimum
55	Protein Variants
13	Purification (Commentary)
3	Reaction
28	Reference
31	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
12	Subunits
40	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
27	Turnover Number [1/s]

Expression

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Expression on EC 4.3.3.6 - pyridoxal 5'-phosphate synthase (glutamine hydrolysing)

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expression of pdxS and pdxT is significantly reduced in the presence of pyridoxal or pyridoxal 5'-phosphate, whereas supplementing with pyridoxamine or pyridoxine shows no effect on pdxST expression

2 entries

the transcription regulator PdxR controls the biosynthesis of pyridoxal or pyridoxal 5'-phosphate in Corynebacterium glutamicum by activating the expression of the pyridoxal or pyridoxal 5'-phosphate synthase genes pdxST

2 entries