4.2.3.42: aphidicolan-16beta-ol synthase

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For detailed information about aphidicolan-16beta-ol synthase, go to the full flat file.

Reaction

Synonyms

ACS, PbACS

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.42 aphidicolan-16beta-ol synthase

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2	AA Sequence
1	Application
1	CAS Registry Number
2	Cloned(Commentary)
4	General Information
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
4	Organism
2	Pathway
11	Protein Variants
2	Reaction
4	Reference
4	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name

Application

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Application on EC 4.2.3.42 - aphidicolan-16beta-ol synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

synthesis

Neocamarosporium betae

Q96WT2

synthesis of aphidicolin, inhibitor of DNA polymerase alpha, by heterologous expression of the genes encoding geranlygeranyl diphosphate synthase, aphidicolan-16beta-ol synthase, and monooxygenases P450-1 and P450-1 from Phoma betae in Aspergillus oryzae. Host Saccharomyces cerevisiae, carrying the genes encoding geranlygeranyl diphosphate synthase and aphidicolan-16beta-ol, produces aphidicolan-16beta-ol

714535