Literature summary for 4.2.3.42 extracted from

Fujii, R.; Minami, A.; Tsukagoshi, T.; Sato, N.; Sahara, T.; Ohgiya, S.; Gomi, K.; Oikawa, H.
Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha: heterologous expression of four biosynthetic genes in Aspergillus oryzae (2011), Biosci. Biotechnol. Biochem., 75, 1813-1817.

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Application

Application	Comment	Organism
synthesis	synthesis of aphidicolin, inhibitor of DNA polymerase alpha, by heterologous expression of the genes encoding geranlygeranyl diphosphate synthase, aphidicolan-16beta-ol synthase, and monooxygenases P450-1 and P450-1 from Phoma betae in Aspergillus oryzae. Host Saccharomyces cerevisiae, carrying the genes encoding geranlygeranyl diphosphate synthase and aphidicolan-16beta-ol, produces aphidicolan-16beta-ol	Neocamarosporium betae

Organism

Organism	UniProt	Comment	Textmining
Neocamarosporium betae	Q96WT2	-	-

Synonyms

Synonyms	Comment	Organism
ACS	-	Neocamarosporium betae

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Release 2023.1 (January 2023)