4.2.3.42: aphidicolan-16beta-ol synthase
This is an abbreviated version!
For detailed information about aphidicolan-16beta-ol synthase, go to the full flat file.
Reaction
Synonyms
ACS, PbACS
ECTree
4.2.3.42 aphidicolan-16beta-ol synthaseAdvanced search results
results (
results (Engineering
Engineering on EC 4.2.3.42 - aphidicolan-16beta-ol synthase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C831G
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
C831T
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
D661A
site-directed mutagenesis, the mutation results in a premature termination of the cyclization reaction cascade en-route from syn-copalyl diphosphate to aphidicolan-16-beta-ol, the mutant generates the diterpene macrocycle syn-copalol and a minor, non-hydroxylated labdane related diterpene
F629L
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
T920G
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
Y658F
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
Y658L
site-directed mutagenesis, the mutation results in a premature termination of the cyclization reaction cascade en-route from syn-copalyl diphosphate to aphidicolan-16-beta-ol, the mutant generates the diterpene macrocycle syn-copalol and a minor, non-hydroxylated labdane related diterpene
Y923F
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
