4.2.3.13: (+)-delta-cadinene synthase

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For detailed information about (+)-delta-cadinene synthase, go to the full flat file.

Reaction

Synonyms

(+)-delta-cadinene synthase, (+)-delta-cadinene synthase isoenzyme XC1, 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-alpha-cadinene-forming), bifunctional sesquiterpene synthase 1, CAD, cadinene synthase, cadinol/cadinene synthase, CDN1, Cdn1-C1, Cdn1-C14, Cop4, cyclase, delta-cadinene, DCS, Dcs1, delta-cadinene cyclase, delta-cadinene synthase, EC 4.6.1.11, farnesyl diphosphate-delta-cadinene cyclase, PnCO/CDS, PnTPS2, sesquiterpene synthase, TPS1, TPS2

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.13 (+)-delta-cadinene synthase

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Results	in table
1182	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Crystallization (Commentary)
2	Expression
10	General Information
1	General Stability
1	IC50 Value
1	Inhibitors
19	kcat/KM [mM/s]
30	KM Value [mM]
7	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
45	Organism
5	Pathway
4	PDB ID
4	pH Optimum
2	pH Range
28	Protein Variants
12	Purification (Commentary)
4	Reaction
2	Reaction Type
28	Reference
30	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
37	Substrates and Products (Substrate)
5	Subunits
34	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
25	Turnover Number [1/s]

Application

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Application on EC 4.2.3.13 - (+)-delta-cadinene synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Gossypium hirsutum

-

RNAi is used to disrupt gossypol biosynthesis in cotton seed tissue by interfering with the expression of the delta-cadinene synthase gene during seed development. It is possible to significantly reduce cottonseed-gossypol levels in a stable and heritable manner. The levels of gossypol and related terpenoids in the foliage and floral parts are not diminished, and thus their potential function in plant defense against insects and diseases remains untouched. A targeted genetic modification, applied to an underutilized agricultural byproduct, provides a mechanism to open up a new source of nutrition for hundreds of millions of people

682520

synthesis

Ricinus communis

B9S9Z3

expression in Saccharomyces cerevisiae leads to a titer of (-)-alpha-copaene of 9 mg/l at 48 h and around 7 mg/l in Escherichia coli, and the titer of (+)-delta-cadinene is 6 mg/l in Saccharomyces cerevisiae and 3.5 mg/l in Escherichia coli

720640