4.2.3.129: (+)-sativene synthase

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For detailed information about (+)-sativene synthase, go to the full flat file.

Reaction

Synonyms

Cop4, sesquiterpene synthase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.129 (+)-sativene synthase

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Results	in table
1	Activating Compound
1	AA Sequence
3	Cloned(Commentary)
7	General Information
4	KM Value [mM]
4	Metals/Ions
5	Natural Substrates/ Products (Substrates)
5	Organism
1	pH Optimum
1	pH Range
7	Protein Variants
1	Reaction
5	Reference
1	Source Tissue
8	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

pH Range

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pH Range on EC 4.2.3.129 - (+)-sativene synthase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Coprinopsis cinerea

A8NU13

changing the pH of the reaction drastically alters the fidelity of Cop4 and makes it a highly selective enzyme. Increasing the reaction temperature to 37°C decreases the fidelity of Cop4. At this temperature Cop4 generates a relative larger fraction of products beta-cubebene, sativene, delta-cadinene and beta-copaene, that are derived from a cadinyl cation intermediate. The histidine side chain in the Cop4 loop, in particular, has a strong impact on the net charge of the loop at different pH values

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