4.2.1.170: 2-(omega-methylthio)alkylmalate dehydratase
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For detailed information about 2-(omega-methylthio)alkylmalate dehydratase, go to the full flat file.
Reaction
Synonyms
IPMI, isopropylmalate dehydratase, isopropylmalate isomerase
ECTree
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General Information
General Information on EC 4.2.1.170 - 2-(omega-methylthio)alkylmalate dehydratase
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malfunction
metabolism
isopropylmalate isomerase (IPMI) large subunit mutants reveal accumulation of intermediates of both Leu biosynthesis and Met chain elongation, and an altered composition of aliphatic glucosinolates demonstrating the function of this gene in both pathways In contrast, the small subunits appear to be specialized to either Leu biosynthesis, EC 4.2.1.133, or Met chain elongation, EC 4.2.1.170, metabolic profiling, overview
malfunction
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isopropylmalate isomerase (IPMI) large subunit mutants reveal accumulation of intermediates of both Leu biosynthesis and Met chain elongation, and an altered composition of aliphatic glucosinolates demonstrating the function of this gene in both pathways In contrast, the small subunits appear to be specialized to either Leu biosynthesis, EC 4.2.1.133, or Met chain elongation, EC 4.2.1.170, metabolic profiling, overview
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the enzyme is involved in methine elongation and in glucosinolate core biosynthesis and side-chain modification. IPMI small subunits are imported into the chloroplast, the localization of the Met chain elongation pathway in these organelles. The large IPMI subunit is involved in both Leu and glucosinolate metabolism, while the small subunits appear to be specific for each pathway. The small subunits IPMI SSU2 and IPMI SSU3 function in Met chain elongation
metabolism
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the enzyme is involved in methine elongation and in glucosinolate core biosynthesis and side-chain modification. IPMI small subunits are imported into the chloroplast, the localization of the Met chain elongation pathway in these organelles. The large IPMI subunit is involved in both Leu and glucosinolate metabolism, while the small subunits appear to be specific for each pathway. The small subunits IPMI SSU2 and IPMI SSU3 function in Met chain elongation
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