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Literature summary for 4.2.1.170 extracted from

  • Knill, T.; Reichelt, M.; Paetz, C.; Gershenzon, J.; Binder, S.
    Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation (2009), Plant Mol. Biol., 71, 227-239.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.170

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-(2-methylthio)ethylmalate Arabidopsis thaliana
-
 2-(2-methylthio)ethylmaleate + H2O
-
 ?
2-(2-methylthio)ethylmalate Arabidopsis thaliana Col-0
-
 2-(2-methylthio)ethylmaleate + H2O
-
 ?
2-(3-methylthio)propylmalate Arabidopsis thaliana
-
 3-(3-methylthio)propylmaleate + H2O
-
 ?
2-(3-methylthio)propylmalate Arabidopsis thaliana Col-0
-
 3-(3-methylthio)propylmaleate + H2O
-
 ?
additional information Arabidopsis thaliana the enzyme catalyzes a two-step reaction via a dehydration of 2-(2-methylthio)ethylmalate and a hydration resulting in an isomerization at position 2/3 to form 3-(2-methylthio)ethylmalate ?
-
 ?
additional information Arabidopsis thaliana Col-0 the enzyme catalyzes a two-step reaction via a dehydration of 2-(2-methylthio)ethylmalate and a hydration resulting in an isomerization at position 2/3 to form 3-(2-methylthio)ethylmalate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q94AR8 AND Q9LYT7 large subunit and small subunit 2
-
Arabidopsis thaliana Q94AR8 AND Q9ZW85 large subunit and small subunit 3
-
Arabidopsis thaliana Col-0 Q94AR8 AND Q9LYT7 large subunit and small subunit 2
-
Arabidopsis thaliana Col-0 Q94AR8 AND Q9ZW85 large subunit and small subunit 3
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-
seed
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(2-methylthio)ethylmalate
-
 Arabidopsis thaliana 2-(2-methylthio)ethylmaleate + H2O
-
 ?
2-(2-methylthio)ethylmalate
-
 Arabidopsis thaliana Col-0 2-(2-methylthio)ethylmaleate + H2O
-
 ?
2-(3-methylthio)propylmalate
-
 Arabidopsis thaliana 3-(3-methylthio)propylmaleate + H2O
-
 ?
2-(3-methylthio)propylmalate
-
 Arabidopsis thaliana Col-0 3-(3-methylthio)propylmaleate + H2O
-
 ?
additional information the enzyme catalyzes a two-step reaction via a dehydration of 2-(2-methylthio)ethylmalate and a hydration resulting in an isomerization at position 2/3 to form 3-(2-methylthio)ethylmalate Arabidopsis thaliana ?
-
 ?
additional information NMR and mass spectrometric compound determination and analysis, overview Arabidopsis thaliana ?
-
 ?
additional information the enzyme catalyzes a two-step reaction via a dehydration of 2-(2-methylthio)ethylmalate and a hydration resulting in an isomerization at position 2/3 to form 3-(2-methylthio)ethylmalate Arabidopsis thaliana Col-0 ?
-
 ?
additional information NMR and mass spectrometric compound determination and analysis, overview Arabidopsis thaliana Col-0 ?
-
 ?

Synonyms

Synonyms Comment Organism
IPMI
-
 Arabidopsis thaliana
isopropylmalate dehydratase
-
 Arabidopsis thaliana
isopropylmalate isomerase
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction isopropylmalate isomerase (IPMI) large subunit mutants reveal accumulation of intermediates of both Leu biosynthesis and Met chain elongation, and an altered composition of aliphatic glucosinolates demonstrating the function of this gene in both pathways In contrast, the small subunits appear to be specialized to either Leu biosynthesis, EC 4.2.1.133, or Met chain elongation, EC 4.2.1.170, metabolic profiling, overview Arabidopsis thaliana
metabolism the enzyme is involved in methine elongation and in glucosinolate core biosynthesis and side-chain modification. IPMI small subunits are imported into the chloroplast, the localization of the Met chain elongation pathway in these organelles. The large IPMI subunit is involved in both Leu and glucosinolate metabolism, while the small subunits appear to be specific for each pathway. The small subunits IPMI SSU2 and IPMI SSU3 function in Met chain elongation Arabidopsis thaliana