Information on EC 4.2.1.170 - 2-(omega-methylthio)alkylmalate dehydratase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.2.1.170
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RECOMMENDED NAME
GeneOntology No.
2-(omega-methylthio)alkylmalate dehydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 2-[(omega-methylthio)alkyl]malate = a 2-[(omega-methylthio)alkyl]maleate + H2O
show the reaction diagram
(1)
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a 3-[(omega-methylthio)alkyl]malate = a 2-[(omega-methylthio)alkyl]maleate + H2O
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Glucosinolate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
2-[(omega-methylthio)alkyl]malate hydro-lyase (2-[(omega-methylthio)alkyl]maleate-forming)
The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(omega-methylthio)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis.