Information on EC 4.2.1.170 - 2-(omega-methylthio)alkylmalate dehydratase

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The expected taxonomic range for this enzyme is: Arabidopsis thaliana

EC NUMBER
COMMENTARY hide
4.2.1.170
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RECOMMENDED NAME
GeneOntology No.
2-(omega-methylthio)alkylmalate dehydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 2-[(omega-methylthio)alkyl]malate = a 2-[(omega-methylthio)alkyl]maleate + H2O
show the reaction diagram
(1)
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a 3-[(omega-methylthio)alkyl]malate = a 2-[(omega-methylthio)alkyl]maleate + H2O
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glucosinolate biosynthesis
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
2-[(omega-methylthio)alkyl]malate hydro-lyase (2-[(omega-methylthio)alkyl]maleate-forming)
The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(omega-methylthio)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis.
ORGANISM
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LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-(2-methylthio)ethylmalate
2-(3-methylthio)ethylmalate
show the reaction diagram
2-(3-methylthio)propylmalate
3-(3-methylthio)propylmalate
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-(2-methylthio)ethylmalate
2-(3-methylthio)ethylmalate
show the reaction diagram
2-(3-methylthio)propylmalate
3-(3-methylthio)propylmalate
show the reaction diagram
additional information
?
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SOURCE TISSUE
ORGANISM
UNIPROT
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LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE