4.2.1.170: 2-(omega-methylthio)alkylmalate dehydratase

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Reaction

Synonyms

IPMI, isopropylmalate dehydratase, isopropylmalate isomerase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

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8	Substrates and Products (Substrate)
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Systematic Name on EC 4.2.1.170 - 2-(omega-methylthio)alkylmalate dehydratase

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SYSTEMATIC NAME

IUBMB Comments

2-[(omega-methylthio)alkyl]malate hydro-lyase (2-[(omega-methylthio)alkyl]maleate-forming)

The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(omega-methylsulfanyl)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis.