4.2.1.167: (R)-2-hydroxyglutaryl-CoA dehydratase

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For detailed information about (R)-2-hydroxyglutaryl-CoA dehydratase, go to the full flat file.

Reaction

Synonyms

hgdAB, HgdC

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase

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Results	in table
10	Activating Compound
13	AA Sequence
3	Cloned(Commentary)
11	Cofactor
2	General Information
14	kcat/KM [mM/s]
14	KM Value [mM]
9	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
54	Organism
3	Oxidation Stability
4	Pathway
1	pH Optimum
5	Purification (Commentary)
1	Reaction
27	Reference
3	Specific Activity [micromol/min/mg]
6	Storage Stability
42	Substrates and Products (Substrate)
10	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.1.167 - (R)-2-hydroxyglutaryl-CoA dehydratase

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SYSTEMATIC NAME

IUBMB Comments

(R)-2-hydroxyglutaryl-CoA hydro-lyase ((E)-glutaconyl-CoA-forming)

The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4Fe-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers.