4.2.1.167: (R)-2-hydroxyglutaryl-CoA dehydratase
This is an abbreviated version!
For detailed information about (R)-2-hydroxyglutaryl-CoA dehydratase, go to the full flat file.
Reaction
Synonyms
hgdAB, HgdC
ECTree
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Substrates Products
Substrates Products on EC 4.2.1.167 - (R)-2-hydroxyglutaryl-CoA dehydratase
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REACTION DIAGRAM
butynedioyl-CoA
oxaloacetate + CoA
Q9X5B7; Q9X5B8
-
initial products are 2-hydroxyfumaroyl-CoA or 2-hydroxymalyl-CoA which tautomerize to oxaloacetyl-CoA. The latter spontaneously hydrolyzes to oxaloacetate and coenzyme A
-
?
muconyl-CoA
?
Q9X5B7; Q9X5B8
hydration of butynedioyl-CoA most likely leads to 2-oxosuccinyl-CoA, which spontaneously hydrolyzes to oxaloacetate and CoASH
-
-
r
S-(R)-2-hydroxyglutarylpantetheine
S-(E)-glutaconylpantetheine + H2O
Q9X5B7; Q9X5B8
-
-
-
r
(E)-glutaconyl-CoA + H2O
(R)-2-hydroxyglutaryl-CoA
-
-
-
-
r
(E)-glutaconyl-CoA + H2O
(R)-2-hydroxyglutaryl-CoA
Q9X5B7; Q9X5B8
-
-
-
r
(E)-glutaconyl-CoA + H2O
(R)-2-hydroxyglutaryl-CoA
Q9X5B7; Q9X5B8
-
-
-
r
(2R)-2-hydroxy-5-oxoadipyl-CoA
Q9X5B7; Q9X5B8
-
-
-
r
(E)-oxalocrotonyl-CoA + H2O
(2R)-2-hydroxy-5-oxoadipyl-CoA
Q9X5B7; Q9X5B8
-
-
-
r
(2R,4E)-2-hydroxy-4-hexenedioyl-CoA
Q9X5B7; Q9X5B8
-
-
-
r
(E,E)-muconyl-CoA + H2O
(2R,4E)-2-hydroxy-4-hexenedioyl-CoA
Q9X5B7; Q9X5B8
-
-
-
r
(E)-2-hexenedioyl-CoA + H2O
Q9X5B7; Q9X5B8
-
-
-
r
(R)-2-hydroxyadipyl-CoA
(E)-2-hexenedioyl-CoA + H2O
Q9X5B7; Q9X5B8
-
-
-
r
(E)-glutaconyl-CoA + H2O
-
-
-
?
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
-
-
-
?
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
-
-
-
r
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
the enzyme is involved in the fermentation of L-glutamate
-
-
?
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
-
-
-
-
r
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
-
-
-
r
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
-
-
-
?, r
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
the enzyme is involved in the fermentation of L-glutamate
-
-
?
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
-
-
-
?
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
Q9X5B7; Q9X5B8
-
-
-
r
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
Q9X5B8; Q9X5B7
-
-
-
r
(R)-2-hydroxyglutaryl-CoA
(E)-glutaconyl-CoA + H2O
Q9X5B7; Q9X5B8
-
-
-
r
(E)-glutaconyl-N-acetylcysteamine + H2O
Q9X5B7; Q9X5B8
-
-
-
r
(R)-2-hydroxyglutaryl-N-acetylcysteamine
(E)-glutaconyl-N-acetylcysteamine + H2O
Q9X5B7; Q9X5B8
-
-
-
r
?
-
in the presence of ATP one electron is transferred from flavodoxin hydroquinone via the [4Fe-4S]1+/2+ cluster of the activator protein to Mo(VI) of heterodimeric dehydratase, which is thereby reduced to Mo(V)
-
-
?
additional information
?
-
in the presence of ATP one electron is transferred from flavodoxin hydroquinone via the [4Fe-4S]1+/2+ cluster of the activator protein to Mo(VI) of heterodimeric dehydratase, which is thereby reduced to Mo(V)
-
-
?
additional information
?
-
-
no activity with 3-methylglutaconyl-CoA. The dehydratase is not specific for the CoA-moiety because (R)-2-hydroxyglutaryl-thioesters of N-acetylcysteamine and pantetheine serve as almost equal substrates
-
-
?
additional information
?
-
Q9X5B7; Q9X5B8
no activity with 3-methylglutaconyl-CoA. The dehydratase is not specific for the CoA-moiety because (R)-2-hydroxyglutaryl-thioesters of N-acetylcysteamine and pantetheine serve as almost equal substrates
-
-
?
additional information
?
-
-
no activity with 3-methylglutaconyl-CoA. The dehydratase is not specific for the CoA-moiety because (R)-2-hydroxyglutaryl-thioesters of N-acetylcysteamine and pantetheine serve as almost equal substrates
-
-
?
additional information
?
-
Q9X5B7; Q9X5B8
no activity with 3-methylglutaconyl-CoA. The dehydratase is not specific for the CoA-moiety because (R)-2-hydroxyglutaryl-thioesters of N-acetylcysteamine and pantetheine serve as almost equal substrates
-
-
?