4.2.1.167: (R)-2-hydroxyglutaryl-CoA dehydratase

This is an abbreviated version!
For detailed information about (R)-2-hydroxyglutaryl-CoA dehydratase, go to the full flat file.

Reaction

Synonyms

hgdAB, HgdC

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase

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Results	in table
10	Activating Compound
13	AA Sequence
3	Cloned(Commentary)
11	Cofactor
2	General Information
14	kcat/KM [mM/s]
14	KM Value [mM]
9	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
54	Organism
3	Oxidation Stability
4	Pathway
1	pH Optimum
5	Purification (Commentary)
1	Reaction
27	Reference
3	Specific Activity [micromol/min/mg]
6	Storage Stability
42	Substrates and Products (Substrate)
10	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

KM Value

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KM Value on EC 4.2.1.167 - (R)-2-hydroxyglutaryl-CoA dehydratase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.25

(E)-glutaconyl-CoA

2 entries

1.1

(E)-oxalocrotonyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

0.57

(E,E)-muconyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

0.1

(R)-2-hydroxyadipyl-CoA

2 entries

0.052

(R)-2-hydroxyglutaryl-CoA

2 entries

0.115

(R)-2-hydroxyglutaryl-N-acetylcysteamine

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

2.1

butynedioyl-CoA

2 entries

0.57

muconyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

pH 8.0, 21°C

733328

1.1

oxalocrotonyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

pH 8.0, 21°C

733328

0.09

S-(R)-2-hydroxyglutarylpantetheine

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

0.25

(E)-glutaconyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

pH 8.0, 21°C

733328

0.25

(E)-glutaconyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

0.1

(R)-2-hydroxyadipyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

pH 8.0, 21°C

733328

0.1

(R)-2-hydroxyadipyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

0.052

(R)-2-hydroxyglutaryl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

pH 8.0, 21°C

733328

0.052

(R)-2-hydroxyglutaryl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328

2.1

butynedioyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

pH 8.0, 21°C

733328

2.1

butynedioyl-CoA

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328