4.2.1.167: (R)-2-hydroxyglutaryl-CoA dehydratase

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For detailed information about (R)-2-hydroxyglutaryl-CoA dehydratase, go to the full flat file.

Reaction

Synonyms

hgdAB, HgdC

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase

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Results	in table
10	Activating Compound
13	AA Sequence
3	Cloned(Commentary)
11	Cofactor
2	General Information
14	kcat/KM [mM/s]
14	KM Value [mM]
9	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
54	Organism
3	Oxidation Stability
4	Pathway
1	pH Optimum
5	Purification (Commentary)
1	Reaction
27	Reference
3	Specific Activity [micromol/min/mg]
6	Storage Stability
42	Substrates and Products (Substrate)
10	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 4.2.1.167 - (R)-2-hydroxyglutaryl-CoA dehydratase

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.0558

Acidaminococcus fermentans

P11569; P11570

pH 7.0, 37°C

733761

32

[Clostridium] symbiosum

Q9X5B7; Q9X5B8, Q9X5B8; Q9X5B7

strictly anaerobic conditions, substrate (R)-2-hydroxyglutaryl-CoA, 200 mM potassium phosphate pH 7.0, 22°C

733766

54

[Clostridium] symbiosum

Q9X5B7; Q9X5B8

substrate (R)-2-hydroxyglutaryl-CoA, strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

733328