4.2.1.154: tetracenomycin F2 cyclase

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For detailed information about tetracenomycin F2 cyclase, go to the full flat file.

Reaction

Synonyms

Tcm F2 cyclase, tcmI, TcmI cyclase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.154 tetracenomycin F2 cyclase

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Results	in table
10	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
8	kcat/KM [mM/s]
9	KM Value [mM]
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
7	Pathway
1	pH Range
7	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reference
2	Specific Activity [micromol/min/mg]
4	Substrates and Products (Substrate)
5	Subunits
8	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.1.154 - tetracenomycin F2 cyclase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

tetracenomycin F2

tetracenomycin F1 + H2O

4 entries

tetracenomycin F2

tetracenomycin F1 + H2O

Streptomyces glaucescens

-

-

722482

-

-

?

tetracenomycin F2

tetracenomycin F1 + H2O

Streptomyces glaucescens

P39890

-

729963

-

-

?

tetracenomycin F2

tetracenomycin F1 + H2O

Streptomyces glaucescens

-

at pH 8.0 or higher, the enzyme catalyzes the cyclization of tetracenomycin F2 to tetracenomycin F1, while below pH 6.5, the enzyme catalyzes the cyclization of tetracenomycin F2 to 9-decarboxy-tetracenomycin F1

729187

-

-

?

tetracenomycin F2

tetracenomycin F1 + H2O

Streptomyces glaucescens WMH1068

-

at pH 8.0 or higher, the enzyme catalyzes the cyclization of tetracenomycin F2 to tetracenomycin F1, while below pH 6.5, the enzyme catalyzes the cyclization of tetracenomycin F2 to 9-decarboxy-tetracenomycin F1

729187

-

-

?