4.2.1.154: tetracenomycin F2 cyclase

This is an abbreviated version!
For detailed information about tetracenomycin F2 cyclase, go to the full flat file.

Reaction

Synonyms

Tcm F2 cyclase, tcmI, TcmI cyclase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.154 tetracenomycin F2 cyclase

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Results	in table
10	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
8	kcat/KM [mM/s]
9	KM Value [mM]
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
7	Pathway
1	pH Range
7	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reference
2	Specific Activity [micromol/min/mg]
4	Substrates and Products (Substrate)
5	Subunits
8	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

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Engineering on EC 4.2.1.154 - tetracenomycin F2 cyclase

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D27N

Streptomyces glaucescens

P39890

the mutant shows 14% activity compared to the wild type enzyme

729963

H26A

Streptomyces glaucescens

P39890

the mutant shows 15% activity compared to the wild type enzyme

729963

H26Q

Streptomyces glaucescens

P39890

the mutant shows 91% activity compared to the wild type enzyme

729963

H51A

Streptomyces glaucescens

P39890

the mutant shows 16% activity compared to the wild type enzyme

729963

H51Q

Streptomyces glaucescens

P39890

the mutant shows 96% activity compared to the wild type enzyme

729963

R40G

Streptomyces glaucescens

P39890

the mutant shows 10% activity compared to the wild type enzyme

729963

R40K

Streptomyces glaucescens

P39890

the mutant shows 16% activity compared to the wild type enzyme

729963