4.2.1.136: ADP-dependent NAD(P)H-hydrate dehydratase

This is an abbreviated version!
For detailed information about ADP-dependent NAD(P)H-hydrate dehydratase, go to the full flat file.

Reaction

(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

Synonyms

ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP/ATP-dependent NAD(P)H-hydrate dehydratase, BSU38720, Carkd, More, NAD(P)H-hydrate dehydratase, NAD(P)HX dehydratase, NADHX dehydratase, NNRD, Tm0922, YjeF, YKL151C, YxkO

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.136 ADP-dependent NAD(P)H-hydrate dehydratase

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Results	in table
38641	AA Sequence
3	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
19	General Information
4	kcat/KM [mM/s]
4	KM Value [mM]
12	Localization
4	Metals/Ions
8	Natural Substrates/ Products (Substrates)
10	Organism
2	Pathway
6	pH Optimum
5	Protein Variants
3	Purification (Commentary)
2	Reaction
10	Reference
7	Source Tissue
21	Substrates and Products (Substrate)
21	Synonyms
6	Temperature Optimum [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.1.136 - ADP-dependent NAD(P)H-hydrate dehydratase

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ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

AMP + phosphate + NADH

2 entries

ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

AMP + phosphate + NADPH

2 entries

ADP + NADHX

AMP + phosphate + NADH

Escherichia coli

YjeF is bi-functional and ADP-dependent. YjeF not only dehydrates (S)-NAD(P)HX, but also interconverts (R)- and (S)-NAD(P)HX. For YjeF, (S)-NADPHX is a better substrate for this enzyme than (S)-NADHX, as indicated by a 2fold higher catalytic efficiency with (S)-NADPHX

719988

ATP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

ADP + phosphate + NADH

6 entries

ATP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

ADP + phosphate + NADPH

6 entries

ATP + NADHX

ADP + phosphate + NADH

2 entries

additional information

4 entries