4.2.1.135: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

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For detailed information about UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining), go to the full flat file.

Reaction

Synonyms

Bc3750, BC_3750, Cj1120c, Pdeg, PglF, UDP-Glc-NAc 4,6-dehydratase, UDP-N-acetylglucosamine C4,6-dehydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.135 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

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Results	in table
1	Activating Compound
1082	AA Sequence
2	Application
5	Cloned(Commentary)
3	Cofactor
8	General Information
5	Inhibitors
1	KM Value [mM]
2	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
18	Organism
8	Pathway
4	pH Optimum
4	Protein Variants
3	Purification (Commentary)
1	Reaction
9	Reference
11	Substrates and Products (Substrate)
2	Subunits
25	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

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Application on EC 4.2.1.135 - UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

Campylobacter jejuni

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assay targets enzymes involved in the biosynthesis of the unusual bacterial sugar diNAcBac and the transfer of diNAcBac-phosphate to UndP. This multienzyme assay, together with the established assays for the individual enzymes, can be used to screen for inhibitors, and may be used to evaluate substrate flux along the inhibited pathway. This assay is optimized for maximum sensitivity to inhibition of PglF, PglE, PglD, and PglC by balancing the enzyme concentrations such that each is partially rate determining

714453

synthesis

Campylobacter jejuni

-

sugar capsule capsular polysaccharide A (CPSA), which coats the surface of the mammalian symbiont Bacteroides fragilis, is a key mediator of mammalian immune system development, the enzyme, coupled to a Bacteroides fragilis-encoded aminotransferase (WcfR), is used in sythetic construction system for CPSA for synthesis of the rare stereoconfiguration sugar acetamido-4-amino-6-deoxygalactopyranose in a two-step coupled reaction with WcfR, overview

729230