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BRENDA support

4.2.1.135: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

This is an abbreviated version!
For detailed information about UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining), go to the full flat file.

Reaction

UDP-N-acetyl-alpha-D-glucosamine
=
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
+
H2O

Synonyms

Bc3750, BC_3750, Cj1120c, Pdeg, PglF, UDP-Glc-NAc 4,6-dehydratase, UDP-N-acetylglucosamine C4,6-dehydratase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.135 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

Cloned

Cloned on EC 4.2.1.135 - UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed as a His-tagged recombinant protein in Escherichia coli
-
full-length PglF is overexpressed as a GST-fusion protein
-
gene Bc3750, sequence comparisons, recombinant expression of His6-tagged enzyme in Escherichia coli
gene Pdeg or pglF, recombinant expression in Escherichia coli, coexpression with Preq (UDP-4-reductase), UDP-GlcNAc 6-DH (UDP-N-acetylglucosamine 6-dehydrogenase), and UXNAcS (UDP-N-acetylxylosamine synthase), leading to biosynthesis of flavonoid glycosides in the engineered Escherichia coli strain, overview
recombinantly expressed
-