4.1.3.38: aminodeoxychorismate lyase
This is an abbreviated version!
For detailed information about aminodeoxychorismate lyase, go to the full flat file.
Reaction
Synonyms
4-amino-4-deoxychorismate lyase, Abz2, ADC lyase, ADCL, ADCS, aminodeoxychorismate lyase, aminodeoxychorismate synthase, enzyme X, PabC, PabC-1, PabC-2, TTHA0621 protein
ECTree
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Cofactor
Cofactor on EC 4.1.3.38 - aminodeoxychorismate lyase
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pyridoxal 5'-phosphate
dependent on, one molecule of cofactor is deeply buried in the cleft between domains I and II, pyridoxal 5'-phosphate adopts the re-face specificity facing the protein side and is covalently linked to the catalytic residue Lys251 by forming an internal aldimine bond, Schiff base linkage
pyridoxal 5'-phosphate
dependent on, the PLP methyl group makes van der Waals interactions with Gln147 and is positioned 3.2 A distant from the carbonyl oxygen of Val175, Ser237 interacts with the pyridoxal 5'-phosphate phosphate