4.1.3.16: 4-Hydroxy-2-oxoglutarate aldolase
This is an abbreviated version!
For detailed information about 4-Hydroxy-2-oxoglutarate aldolase, go to the full flat file.
Word Map on EC 4.1.3.16
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4.1.3.16
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hyperoxalurias
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oxalate
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stone
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ph2
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grhpr
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hydroxyproline
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urolithiasis
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2-keto-3-deoxy-6-phosphogluconate
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nephrocalcinosis
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alanine-glyoxylate
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nephrolithiasis
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synthesis
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medicine
- 4.1.3.16
- hyperoxalurias
- oxalate
-
stone
- ph2
- grhpr
- hydroxyproline
- urolithiasis
- 2-keto-3-deoxy-6-phosphogluconate
-
nephrocalcinosis
-
alanine-glyoxylate
-
nephrolithiasis
- synthesis
- medicine
Reaction
Synonyms
2-keto-4-hydroxybutyrate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-keto-4-hydroxyglutaric aldolase, 2-oxo-3-deoxy-6-phosphogluconate aldolase, 2-oxo-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 4-hydroxy-2-ketoglutaric aldolase, 4-hydroxy-2-oxoglutarate aldolase, aldolase, 4-hydroxy-2-oxoglutarate, DHDPSL, dihydrodipicolinate synthase-like enzyme, DL-4-Hydroxy-2-ketoglutarate aldolase, EC 4.1.2.1, EC 4.1.2.31, eda, Entner-Doudoroff aldolase, hOGA, HOGA1, hydroxyketoglutarate aldolase, Hydroxyketoglutaric aldolase, KDPGlc aldolase, KHG-aldolase
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Engineering
Engineering on EC 4.1.3.16 - 4-Hydroxy-2-oxoglutarate aldolase
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C257G
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
DeltaE315
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
G287V
P190L
R255X
a truncation of 71 residues from the C-terminus associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
R303C
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
R70P
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
R97C
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
T280I
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
Y39X/R70X
naturally occuring mutations in a patient with type 3 atypical primary hyperoxaluria
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity
natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity