4.1.3.16: 4-Hydroxy-2-oxoglutarate aldolase
This is an abbreviated version!
For detailed information about 4-Hydroxy-2-oxoglutarate aldolase, go to the full flat file.
Word Map on EC 4.1.3.16
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4.1.3.16
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hyperoxalurias
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oxalate
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stone
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ph2
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grhpr
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hydroxyproline
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urolithiasis
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2-keto-3-deoxy-6-phosphogluconate
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nephrocalcinosis
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alanine-glyoxylate
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nephrolithiasis
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synthesis
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medicine
- 4.1.3.16
- hyperoxalurias
- oxalate
-
stone
- ph2
- grhpr
- hydroxyproline
- urolithiasis
- 2-keto-3-deoxy-6-phosphogluconate
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nephrocalcinosis
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alanine-glyoxylate
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nephrolithiasis
- synthesis
- medicine
Reaction
Synonyms
2-keto-4-hydroxybutyrate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-keto-4-hydroxyglutaric aldolase, 2-oxo-3-deoxy-6-phosphogluconate aldolase, 2-oxo-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 4-hydroxy-2-ketoglutaric aldolase, 4-hydroxy-2-oxoglutarate aldolase, aldolase, 4-hydroxy-2-oxoglutarate, DHDPSL, dihydrodipicolinate synthase-like enzyme, DL-4-Hydroxy-2-ketoglutarate aldolase, EC 4.1.2.1, EC 4.1.2.31, eda, Entner-Doudoroff aldolase, hOGA, HOGA1, hydroxyketoglutarate aldolase, Hydroxyketoglutaric aldolase, KDPGlc aldolase, KHG-aldolase
ECTree
4.1.3.16 4-Hydroxy-2-oxoglutarate aldolaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.1.3.16 - 4-Hydroxy-2-oxoglutarate aldolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxy-2-oxoglutarate
?
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catabolism of hydroxyproline, condensation physiologically less important
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?
Glyoxylate + pyruvate
4-Hydroxy-2-ketoglutarate
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higher specificity for pyruvate than for glyoxylate
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?
Glyoxylate + pyruvate
4-Hydroxy-2-ketoglutarate
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specific, codensation favoured, Keq: 0.73 mM
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?
Glyoxylate + pyruvate
4-Hydroxy-2-ketoglutarate
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3-substituted analogs
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-
?
Oxaloacetate
CO2 + pyruvate
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beta-decarboxylation, about 50% as effective as aldolase
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?
additional information
?
-
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functional role of SH-groups, conformational changes during catalysis
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-
?
additional information
?
-
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2-keto-4-hydroxy-4-methylglutarate, 2-keto-3-deoxy-6-phosphoclucanate cleaved at slow rate
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-
?
additional information
?
-
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2-keto-3-deoxyglucarate and 2-keto-4,5-dihydroxyvalerate cleaved at slow rate
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-
?
additional information
?
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enzyme shows no stereospecificity in catalyzing the aldol cleavage of the two optical isomers of 2-keto-4-hydroxyglutarate. Enzyme also catalyzes the beta-decarboxylation of oxalacetate, its decarboxylase/aldolae activity ratio is lower than that seen with the pure enzyme from either bovine liver or Escherichia coli
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-
?
additional information
?
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enzyme performs a retro-aldol cleavage reaction reminiscent of the trimeric 2-keto-3-deoxy-6-phosphogluconate aldolases
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-
?
additional information
?
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enzyme performs a retro-aldol cleavage reaction reminiscent of the trimeric 2-keto-3-deoxy-6-phosphogluconate aldolases
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-
?
additional information
?
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equilibrium favours condensation, Keq: 0.73 1/mM
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-
?
additional information
?
-
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2-keto-3-deoxyglucarate and 2-keto-4,5-dihydroxyvalerate cleaved at slow rate
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-
?
