4.1.2.8: indole-3-glycerol-phosphate lyase

This is an abbreviated version!
For detailed information about indole-3-glycerol-phosphate lyase, go to the full flat file.

Reaction

Synonyms

BX1, IGL, indole synthase, indole-3-glycerol phosphate lyase, indole-3-glycerophosphate D-glyceraldehyde-3-phosphate-lyase, indoleglycerolphosphate hydrolase, INS, Os03g58300, OSJNBa0094F01.14, PtIGL, TRPS, tryptophan synthase alpha, tryptophan synthase alpha subunit, TSA, Tsa1, ZmTSA

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.8 indole-3-glycerol-phosphate lyase

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1	Activating Compound
7	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
3	Crystallization (Commentary)
1	Expression
2	General Information
7	Inhibitors
1	kcat/KM [mM/s]
3	KM Value [mM]
4	Localization
8	Natural Substrates/ Products (Substrates)
15	Organism
6	Pathway
1	pH Optimum
5	Protein Variants
3	Purification (Commentary)
2	Reaction
15	Reference
12	Source Tissue
15	Substrates and Products (Substrate)
1	Subunits
23	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.1.2.8 - indole-3-glycerol-phosphate lyase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,3-dihydroxy-3-[(2-hydroxyphenyl)amino] propyl phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

competetive inhibitor

695226

2-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino) ethyl phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

competetive inhibitor

695226

3-(1H-indol-3-yl)propyl phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

competetive inhibitor

695226

3-(2,3-dihydro-1H-indol-3-yl)glycerol phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

competetive inhibitor

695226

3-acetyl-L-aspartic acid

Salmonella enterica subsp. enterica serovar Typhimurium

-

inhibits the alpha-reaction. Indole 3-acetylglycine and 3-acetyl-L-aspartic acid are similar to complexes that are similar to 3-(1H-indol-3-yl)propyl phosphate with the phosphoryl sub-site occupied by the ligand carboxylate, the indole ring NH H-bonded to alphaAsp60, and one carboxylate oxygen of the catalytic alphaGlu49 H-bonded to the acetyl oxygen

695226

-

4-[(2-aminophenyl)sulfonyl]butyl phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

competetive inhibitor

695226

indole 3-acetylglycine

Salmonella enterica subsp. enterica serovar Typhimurium

-

inhibits the alpha-reaction. Indole 3-acetylglycine and 3-acetyl-L-aspartic acid are similar to complexes that are similar to 3-(1H-indol-3-yl)propyl phosphate with the phosphoryl sub-site occupied by the ligand carboxylate, the indole ring NH H-bonded to alphaAsp60, and one carboxylate oxygen of the catalytic alphaGlu49 H-bonded to the acetyl oxygen

695226