4.1.2.8: indole-3-glycerol-phosphate lyase
This is an abbreviated version!
For detailed information about indole-3-glycerol-phosphate lyase, go to the full flat file.
Word Map on EC 4.1.2.8
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4.1.2.8
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pyridoxal
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l-serine
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l-tryptophan
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aldimine
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alpha-aminoacrylate
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alpha-glycerol
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beta-replacement
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beta-chloro-l-alanine
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benzoxazinoids
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yanofsky
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diboa
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ahmed
- 4.1.2.8
- pyridoxal
- l-serine
- l-tryptophan
-
aldimine
- alpha-aminoacrylate
-
alpha-glycerol
-
beta-replacement
- beta-chloro-l-alanine
-
benzoxazinoids
-
yanofsky
- diboa
-
ahmed
Reaction
Synonyms
BX1, IGL, indole synthase, indole-3-glycerol phosphate lyase, indole-3-glycerophosphate D-glyceraldehyde-3-phosphate-lyase, indoleglycerolphosphate hydrolase, INS, Os03g58300, OSJNBa0094F01.14, PtIGL, TRPS, tryptophan synthase alpha, tryptophan synthase alpha subunit, TSA, Tsa1, ZmTSA
ECTree
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Reaction
Reaction on EC 4.1.2.8 - indole-3-glycerol-phosphate lyase
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(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
the indole is further converted to 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one, a secondary plant metabolite. BX1 cleaves indole-3-glycerol phosphate significantly faster to indole and glyceraldehyde 3-phosphate than the homologous alpha-subunit of tryptophan synthase, EC 4.2.1.20. In the primary metabolism, indole diffuses through the connecting tunnel to the beta-active site where it is condensed with serine to form tryptophan and water