4.1.2.8: indole-3-glycerol-phosphate lyase

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For detailed information about indole-3-glycerol-phosphate lyase, go to the full flat file.

Reaction

Synonyms

BX1, IGL, indole synthase, indole-3-glycerol phosphate lyase, indole-3-glycerophosphate D-glyceraldehyde-3-phosphate-lyase, indoleglycerolphosphate hydrolase, INS, Os03g58300, OSJNBa0094F01.14, PtIGL, TRPS, tryptophan synthase alpha, tryptophan synthase alpha subunit, TSA, Tsa1, ZmTSA

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.8 indole-3-glycerol-phosphate lyase

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Systematic Name

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Systematic Name on EC 4.1.2.8 - indole-3-glycerol-phosphate lyase

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SYSTEMATIC NAME

IUBMB Comments

(1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming)

Forms part of the defence mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyses the first committed step in the formation of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) [1]. This enzyme resembles the alpha-subunit of EC 4.2.1.20, tryptophan synthase [3], for which, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate is also a substrate, but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released [2].