4.1.2.27: sphinganine-1-phosphate aldolase

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For detailed information about sphinganine-1-phosphate aldolase, go to the full flat file.

Reaction

Synonyms

aldolase, dihydrosphingosine 1-phosphate, Dihydrosphingosine 1-phosphate aldolase, dihydrosphingosine phosphate lyase, Dpl1, Dpl1p, LegS2, S-1-P-lyase, S1P lyase, S1P-lyase, S1PL, S1PL2021, Sgpl1, sphinganine 1-phosphate lyase, sphinganine-1-phosphate aldolase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate-alkanal-lyase, sphingosine 1-phosphate lyase, sphingosine phosphate lyase, sphingosine-1-phosphate lyase, sphingosine-phosphate lyase, SPL, SPL1

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.27 sphinganine-1-phosphate aldolase

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Results	in table
114	AA Sequence
16	Application
1	CAS Registry Number
17	Cloned(Commentary)
49	Cofactor
4	Crystallization (Commentary)
466	Disease/ Diagnostics
7	Expression
42	General Information
2	General Stability
66	IC50 Value
224	Inhibitors
1	kcat/KM [mM/s]
14	Ki Value [mM]
13	KM Value [mM]
53	Localization
2	Metals/Ions
12	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
118	Organism
5	Pathway
16	PDB ID
2	pH Optimum
4	Posttranslational Modification
32	Protein Variants
6	Purification (Commentary)
18	Reaction
2	Reaction Type
115	Reference
192	Source Tissue
8	Specific Activity [micromol/min/mg]
4	Storage Stability
141	Substrates and Products (Substrate)
17	Subunits
152	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Expression

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Expression on EC 4.1.2.27 - sphinganine-1-phosphate aldolase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

basal SPL activity is low in wild type cardiac tissue but is activated 3fold in response to 50 min of ischemia

Mus musculus

-

713721

enzyme expression is down-regulated in rice plants after treatments with salicylic acid, benzothiadiazole and 1-amino cyclopropane-1-carboxylic acid

Oryza sativa

-

748935

enzyme expression is increased in brains of patients with Alzheimer's disease

Homo sapiens

-

746682

enzyme expression is induced by infection with a virulent strain of Magnaporthe oryzae

Oryza sativa

-

748935

high SPL transcription of H1155 cells is regulated by specificity protein 1 and GATA-4 protein/specificity protein 1 complex formation

Homo sapiens

-

714336

mRNA expression for both sphingosine kinase and sphingosine 1-phosphate lyase are up-regulated throughout all four stages in human breast cancer patients. Exogenous administration of S1P produces a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells but a sigmoid-shaped apoptotic response in breast cancer MCF7 cells. Co-administration of S1P enhances the cytotoxicity of anticancer drug docetaxel against MCF7 cells

Homo sapiens

-

708817

SGPL1 gene expression is downregulated in colon cancer and is upregulated in certain malignant tissues, for example, in ovarian cancers as well as in the skin of patients suffering from atopic dermatitis

Homo sapiens

-

716860