4.1.2.27: sphinganine-1-phosphate aldolase
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For detailed information about sphinganine-1-phosphate aldolase, go to the full flat file.
Word Map on EC 4.1.2.27
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4.1.2.27
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sphingolipids
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ceramide
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sphingoid
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egress
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lymphopenia
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dihydrosphingosine-1-phosphate
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medicine
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fingolimod
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s1p-degrading
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sphks
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4-deoxypyridoxine
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steroid-resistant
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analysis
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lyase-deficient
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s1p-dependent
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spinster
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s1p-induced
- 4.1.2.27
- sphingolipids
- ceramide
-
sphingoid
-
egress
- lymphopenia
- dihydrosphingosine-1-phosphate
- medicine
- fingolimod
-
s1p-degrading
-
sphks
- 4-deoxypyridoxine
-
steroid-resistant
- analysis
-
lyase-deficient
-
s1p-dependent
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spinster
-
s1p-induced
Reaction
Synonyms
aldolase, dihydrosphingosine 1-phosphate, Dihydrosphingosine 1-phosphate aldolase, dihydrosphingosine phosphate lyase, Dpl1, Dpl1p, LegS2, S-1-P-lyase, S1P lyase, S1P-lyase, S1PL, S1PL2021, Sgpl1, sphinganine 1-phosphate lyase, sphinganine-1-phosphate aldolase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate-alkanal-lyase, sphingosine 1-phosphate lyase, sphingosine phosphate lyase, sphingosine-1-phosphate lyase, sphingosine-phosphate lyase, SPL, SPL1
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Source Tissue
Source Tissue on EC 4.1.2.27 - sphinganine-1-phosphate aldolase
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the cells expressing sphingosine-1-phosphate lyase in the parenchyma o lymph nodes are CD68+ antigen-presenting cells. CD68+ antigen-presenting cells generated from human monocytes are able to internalize and irreversibly degrade sphingosine 1-phosphate
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inhibition of sphingosine-1-phosphate lyase activity rendes sphingosine 1-phosphate an efficient S1P1 receptor internalizing compound and abrogated sphingosine-1-phosphate-mediated sustained signaling, suggesting that sphingosine-1-phosphate lyase by facilitating S1P1 receptor recycling is essential for sphingosine-1-phosphate-mediated sustained signaling, and that synthetic agonists are functional antagonists because they are not sphingosine-1-phosphate lyase substrates
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silencing of sphingosine 1-phosphate lyase enhances survival after irradiation or chemotherapy by decreasing expression of proteins involved in sensing and repairing DNA damage or apoptosis, respectively. Enforced expression of sphingosine 1-phosphate lyase sensitizes cancer cells to irradiation or docetaxel by tilting the ceramide/sphingosine 1-phosphate balance toward cell death
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sphingosine-1-phosphate lyase expression is almost exclusively restricted to cells on the parenchymal side of marginal reticular cells, consistent with a role in maintaining the S1P gradient between the sinuses and the parenchyma
sphingosine-1-phosphate lyase is induced during myoblast differentiation
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of the olfactory bulb, cerebral cortex, midbrain, hindbrain, and cerebellum, high expression rate
the enzyme is highly enriched in olfactory mucosal epithelium
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silencing of sphingosine 1-phosphate lyase enhances survival after irradiation or chemotherapy by decreasing expression of proteins involved in sensing and repairing DNA damage or apoptosis, respectively. Enforced expression of sphingosine 1-phosphate lyase sensitizes cancer cells to irradiation or docetaxel by tilting the ceramide/sphingosine 1-phosphate balance toward cell death
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in fresh human prostatectomy specimens, a remarkable decrease in sphingosine 1-phosphate lyase enzymatic activity is found in tumor samples, as compared with normal adjacent tissues. A significant relationship between loss of sphingosine 1-phosphate lyase expression and higher Gleason score is confirmed. Sphingosine 1-phosphate lyase protein expression and activity are inversely correlated with those of sphingosine kinase-1, the enzyme producing sphingosine 1-phosphate. Sphingosine 1-phosphate lyase and sphingosine kinase expressions are independently predictive of aggressive cancer on tissue microarray
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spingosine 1-phosphate lyase is modestly expressed at day 20 of pregnancy antd then decreases. In contrast, sphingosine 1-phosphate receptor mRNA increases in endometrium and caruncular stroma of the gravid uterine horn
additional information
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no expression in gonad, body wall muscle, pharynx, vulva and epidermis
additional information
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the human SGPL1 gene is ubiquitously expressed with the exception of erythrocytes and platelets and its expression is linked to tissues undergoing rapid cell turnover