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Literature summary for 4.1.2.27 extracted from

  • Ito, H.; Yoshida, K.; Murakami, M.; Hagiwara, K.; Sasaki, N.; Kobayashi, M.; Takagi, A.; Kojima, T.; Sobue, S.; Suzuki, M.; Tamiya-Koizumi, K.; Nakamura, M.; Banno, Y.; Nozawa, Y.; Murate, T.
    Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines (2011), Biochim. Biophys. Acta, 1811, 119-128.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
 x * 63000, SDS-PAGE Homo sapiens
63500
-
 x * 63500, calculated from amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H1155 cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
NCI-H157 cell
-
 Homo sapiens
-
NCI-H2347 cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrosphingosine 1-phosphate
-
 Homo sapiens phosphoethanolamine + palmitaldehyde
-
 ?

Subunits

Subunits Comment Organism
? x * 63000, SDS-PAGE Homo sapiens
? x * 63500, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
sphingosine 1-phosphate lyase
-
 Homo sapiens
sphingosine-1-phosphate lyase
-
 Homo sapiens
SPL
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens high SPL transcription of H1155 cells is regulated by specificity protein 1 and GATA-4 protein/specificity protein 1 complex formation up