4.1.2.17: L-fuculose-phosphate aldolase
This is an abbreviated version!
For detailed information about L-fuculose-phosphate aldolase, go to the full flat file.
Word Map on EC 4.1.2.17
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4.1.2.17
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dihydroxyacetone
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aldolases
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dhap
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l-rhamnulose-1-phosphate
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l-lactaldehyde
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l-ribulose-5-phosphate
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epimerase
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fucose
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dhap-dependent
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iminocyclitols
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epimer
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epimerization
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l-1,2-propanediol
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propanediol
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polyhydroxylated
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synthesis
- 4.1.2.17
- dihydroxyacetone
- aldolases
- dhap
- l-rhamnulose-1-phosphate
- l-lactaldehyde
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l-ribulose-5-phosphate
-
epimerase
- fucose
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dhap-dependent
- iminocyclitols
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epimer
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epimerization
- l-1,2-propanediol
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propanediol
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polyhydroxylated
- synthesis
Reaction
Synonyms
aldolase, L-fuculose phosphate, F-1PA, Fuc-1PA, FucA, fuculose aldolase, fuculose-1-phosphate aldolase, L-Fuc1P aldolase, L-Fuculose 1-phosphate aldolase, L-Fuculose phosphate aldolase, L-Fuculose-1-P aldolase, L-fuculose-1-phosphate aldolase, L-fuculose-phosphate aldolase
ECTree
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Engineering
Engineering on EC 4.1.2.17 - L-fuculose-phosphate aldolase
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F131A
F131A/F206A
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the relative activity of F131A/F206A towards L-fuculose-1-phosphate is approximately less than 0.5% as compared to the wild type enzyme
F206A
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the mutant has 22% retroaldol activity with L-fuculose-1-phosphate as compared to the wild type enzyme
K42M
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mutant with reduced specific activity, can be inhibited by excess Zn2+
Y113A
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the mutant has 0.5% retroaldol activity with L-fuculose-1-phosphate as compared to the wild type enzyme
D25L
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negative effect on catalytic activity and substrate recognition
D25T
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negative effect on catalytic activity and substrate recognition
additional information
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the deletion mutants Del(211-215) and Del(207-215) show 11% and 2% retroaldol activity with L-fuculose-1-phosphate, respectively, as compared to the wild type enzyme
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the mutant has 1% retroaldol activity with L-fuculose-1-phosphate as compared to the wild type enzyme. The mutant uses (R)-N-benzyloxycarbonyl-prolinal as substrate and is highly stereoselective both with (R)-and with (S)-N-benzyloxycarbonyl-prolinal, exclusively producing the anti- and syn-aldol adducts, respectively