4.1.1.81: threonine-phosphate decarboxylase

This is an abbreviated version!
For detailed information about threonine-phosphate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.81

4.1.1.81

enterica

cobalamin

pyridoxal

cobamides

aminotransferases

histidinol

corrin

decarboxylases

dehalogenase

plp-dependent

typhimurium

o-phosphate

escalante-semerena

methanosarcina

aldimine

mazei

metal-binding

Reaction

Synonyms

CobD, CobD gene product, L-Thr kinase/L-Thr-P decarboxylase, L-Thr kinase/L-Thr-phosphate decarboxylase, L-threonine-O-3-phosphate decarboxylase, MM2060, MmCobD, More, SMUL_1544

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.81 threonine-phosphate decarboxylase

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Results	in table
9227	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
12	General Information
1	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
13	Organism
5	Pathway
6	Protein Variants
3	Purification (Commentary)
1	Reaction
10	Reference
19	Substrates and Products (Substrate)
2	Subunits
23	Synonyms
1	Systematic Name

Metals Ions

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Metals Ions on EC 4.1.1.81 - threonine-phosphate decarboxylase

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Fe2+

Methanosarcina mazei

Q8PVB2

the wild-type MmCobD that is normoxically or anoxically purified and then reconstituted, or anoxically purified without reconstitution contains an average of 25 Fe atoms per monomer, with rather poor standard deviations . The C-terminus of MmCobD contains one or more [4Fe-4S] 2+ cluster(s). Although these [4Fe-4S]2+ cluster(s) are not required for activity, perturbations in the C-terminal domain result in the loss of Fe2+ and alterations in the enzyme activities associated with the N-terminus. The C-terminus is not required for the kinase or decarboxylase activities, the [4Fe-4S]2+ cluster-containing C-terminus may have a regulatory role, perhaps by gating the active site or facilitating the decarboxylation and or kinase reactions. Fe2+ is not detected in the N-terminus only (MmCobD1-385) protein sample

760602

additional information

2 entries