4.1.1.71: 2-oxoglutarate decarboxylase

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For detailed information about 2-oxoglutarate decarboxylase, go to the full flat file.

Reaction

Synonyms

ALKBH4, alpha-ketoglutarate decarboxylase, alpha-ketoglutaric decarboxylase, alpha-KGD, decarboxylase, oxoglutarate, E1o, Fe(II)/2OG-dependent decarboxylase, KDC, Kgd, oxoglutarate decarboxylase, pre-2-oxoglutarate decarboxylase, Rv1248c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.71 2-oxoglutarate decarboxylase

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Results	in table
18	Activating Compound
3178	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
15	Cofactor
3	Crystallization (Commentary)
36	Disease/ Diagnostics
1	General Information
1	General Stability
29	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
4	Localization
16	Metals/Ions
5	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
211	Organism
1	Pathway
62	PDB ID
4	pH Optimum
5	pH Range
1	pH Stability
1	pI Value
2	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
17	Reference
1	Source Tissue
1	Storage Stability
25	Substrates and Products (Substrate)
9	Subunits
23	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

General Information

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General Information on EC 4.1.1.71 - 2-oxoglutarate decarboxylase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Trypanosoma brucei

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Despite the lack of a functional Krebs cycle, x02alpha-KDE1 is expressed in bloodstream form of Trypanosoma brucei. RNAi treatment of alpha-KDE1 mRNA results in rapid growth arrest and killing. Cell death is preceded by progressive swelling of the flagellar pocket as a consequence of recruitment of both flagellar and plasma membranes into the pocket

747683